Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHCR24 | Q15392 | 12/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | USP2 | O75604 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.77 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30570379 | 1.00 | DHCR24 (1.00) | DHCR24ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL26237720 | 1.00 | DHCR24 (1.00) | DHCR24ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL26237531 | 1.00 | DHCR24 (1.00) | DHCR24ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL26236481 | 1.00 | DHCR24 (1.00) | DHCR24ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL25391791 | 1.00 | DHCR24 (1.00) | DHCR24ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL25390650 | 1.00 | DHCR24 (1.00) | DHCR24ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL25390651 | 1.00 | DHCR24 (1.00) | DHCR24ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL25391789 | 1.00 | DHCR24 (1.00) | DHCR24ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL26237313 | 0.90 | DHCR24 (0.81) | DHCR24ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL14911153 | 0.89 | ALDH1A1 (0.80) | DHCR24ALDH1A1MEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250312355-A1 | DHCR24 INHIBITORY COMPOUNDS | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) (NL) | 2025-10-09 | — | — | US | disclosed |
| EP-4489762-A1 | DHCR24 INHIBITORY COMPOUNDS | Academisch Ziekenhuis Leiden (h.o.d.n. LUMC) (NL) | 2025-01-15 | — | — | EP | disclosed |
| CN-118973585-A | DHCR24 inhibiting compounds | 莱顿教学医院 | 2024-11-15 | — | — | CN | disclosed |
| WO-2023172132-A1 | DHCR24 INHIBITORY COMPOUNDS | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) (NL) | 2023-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250312355-A1 | DHCR24 INHIBITORY COMPOUNDS | DHCR7, CYP46A1, CYP27A1 | DHCR24 4/4885ALDH1A1 814/4885MEN1 3790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.