Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | TSSK2 | Q96PF2 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.32 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25397536 | 0.81 | ADORA1 (0.37) | TGFBR1TGFBR2ADORA2AADORA1 | |
| SCHEMBL25396550 | 0.79 | ADORA2A (0.42) | ALDH1A1KDM4ENPC1MAPTRAB9A | |
| SCHEMBL25394773 | 0.78 | MAPKAPK2 (0.36) | NAPRTMAPKAPK2CHEK1TGFBR1JAK2 | |
| SCHEMBL29267302 | 0.69 | KDM4E (0.35) | MAPKAPK2CHEK1ALDH1A1KDM4EMAPT | |
| SCHEMBL29267278 | 0.66 | CCR2 (0.33) | ALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL17437979 | 0.65 | KDM4E (0.35) | ALDH1A1KDM4ETGFBR1IGF1RADORA2A | |
| SCHEMBL30776027 | 0.65 | NAPRT (0.37) | NAPRTALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL25395169 | 0.65 | HDAC8 (0.50) | ALDH1A1KDM4ENPC1MAPTRAB9A | |
| SCHEMBL3632923 | 0.64 | MEN1 (0.43) | NAPRTMAPKAPK2ALDH1A1SIRT6TDP1 | |
| SCHEMBL6177612 | 0.64 | GABRP (0.41) | NAPRTALDH1A1KDM4ENPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250213571-A1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC. | 2025-07-03 | — | — | US | disclosed |
| EP-4493562-A1 | TYK2 INHIBITORS AND USES THEREOF | Alumis Inc. (US) | 2025-01-22 | — | — | EP | disclosed |
| WO-2023178235-A1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2023178235-A1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC. (US) | 2023-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250213571-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK1, JAK2 | NAPRT 2444/4885MAPKAPK2 60/4885CHEK1 592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.