Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 18/20 | 0.71 |
| ▸ | SRC | P12931 | 9/20 | 0.68 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.68 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.68 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.68 |
| ▸ | WEE1 | P30291 | 4/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.64 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.64 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.64 |
| ▸ | EGFR | P00533 | 5/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | PAK4 | O96013 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25397994 | 0.86 | SRC (0.67) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL30618362 | 0.85 | FGFR1 (0.72) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL25398482 | 0.85 | FGFR1 (0.72) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL25399979 | 0.84 | FGFR1 (0.82) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL26257902 | 0.84 | FGFR1 (0.79) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL30618238 | 0.83 | FGFR1 (0.61) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL25396206 | 0.83 | FGFR1 (0.61) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL868129 | 0.83 | FGFR1 (1.00) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL25400645 | 0.82 | FGFR1 (0.59) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL25435911 | 0.82 | FGFR1 (0.59) | FGFR1SRCFGFR2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023177356-A2 | COMPOUNDS AND METHOD FOR PKMYT1 INHIBITION | ENGINE BIOSCIENCES PTE. LTD. (SG) | 2023-09-21 | — | — | WO | disclosed |
| WO-2023177356-A2 | COMPOUNDS AND METHOD FOR PKMYT1 INHIBITION | ENGINE BIOSCIENCES PTE. LTD. (SG) | 2023-09-21 | — | — | WO | disclosed |