Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 4/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.61 |
| ▸ | SRC | P12931 | 11/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.61 |
| ▸ | EGFR | P00533 | 5/20 | 0.60 |
| ▸ | ABL1 | P00519 | 7/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.59 |
| ▸ | KIT | P10721 | 3/20 | 0.59 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.57 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.57 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30618292 | 1.00 | WEE1 (0.61) | WEE1FGFR1SRCPDGFRBPDGFRA | |
| SCHEMBL25400254 | 0.92 | FGFR1 (0.62) | WEE1FGFR1SRCPDGFRBPDGFRA | |
| SCHEMBL25397994 | 0.87 | SRC (0.67) | WEE1FGFR1SRCPDGFRBPDGFRA | |
| SCHEMBL26257902 | 0.84 | FGFR1 (0.79) | WEE1FGFR1SRCPDGFRBPDGFRA | |
| SCHEMBL25399849 | 0.82 | WEE1 (0.60) | WEE1FGFR1SRCPDGFRBPDGFRA | |
| SCHEMBL25399847 | 0.82 | WEE1 (0.60) | WEE1FGFR1SRCPDGFRBPDGFRA | |
| SCHEMBL25399979 | 0.81 | FGFR1 (0.82) | WEE1FGFR1SRCPDGFRBPDGFRA | |
| SCHEMBL25399236 | 0.80 | FGFR1 (0.71) | WEE1FGFR1SRCPDGFRBPDGFRA | |
| SCHEMBL25399720 | 0.80 | FGFR1 (0.60) | WEE1FGFR1SRCPDGFRBPDGFRA | |
| SCHEMBL25401199 | 0.80 | FGFR1 (0.60) | WEE1FGFR1SRCPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023177356-A2 | COMPOUNDS AND METHOD FOR PKMYT1 INHIBITION | ENGINE BIOSCIENCES PTE. LTD. (SG) | 2023-09-21 | — | — | WO | disclosed |
| WO-2023177356-A2 | COMPOUNDS AND METHOD FOR PKMYT1 INHIBITION | ENGINE BIOSCIENCES PTE. LTD. (SG) | 2023-09-21 | — | — | WO | disclosed |