Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.65 |
| ▸ | BRAF | P15056 | 1/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.65 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.65 |
| ▸ | CSF1R | P07333 | 4/20 | 0.62 |
| ▸ | RET | P07949 | 4/20 | 0.58 |
| ▸ | FLT3 | P36888 | 5/20 | 0.56 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25404330 | 0.90 | CSF1R (0.60) | KDRBRAFMAPK14TNNI3KCSF1R | |
| SCHEMBL2847973 | 0.89 | KDR (0.74) | KDRBRAFMAPK14TNNI3KCSF1R | |
| SCHEMBL25405811 | 0.88 | KDR (0.81) | KDRBRAFMAPK14TNNI3KCSF1R | |
| SCHEMBL30564552 | 0.82 | JAK2 (0.49) | KDRBRAFMAPK14TNNI3KCSF1R | |
| SCHEMBL12975650 | 0.81 | NR2E1 (0.55) | KDRBRAFMAPK14TNNI3KCSF1R | |
| SCHEMBL25404649 | 0.81 | CSF1R (0.76) | KDRBRAFCSF1RRETFLT3 | |
| SCHEMBL26272089 | 0.80 | KDR (0.66) | KDRBRAFMAPK14TNNI3KCSF1R | |
| SCHEMBL25405443 | 0.79 | PDGFRB (0.64) | KDRBRAFCSF1RFLT3PDGFRB | |
| SCHEMBL25405161 | 0.79 | CSF1R (0.61) | KDRBRAFMAPK14TNNI3KCSF1R | |
| SCHEMBL25403198 | 0.79 | CSF1R (0.63) | KDRBRAFMAPK14TNNI3KCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116789670-A | Selective CSF1R inhibitor and application thereof | 中国科学院合肥物质科学研究院 | 2023-09-22 | — | — | CN | disclosed |
| WO-2023173480-A1 | SELECTIVE CSF1R INHIBITOR AND USE THEREOF | 中国科学院合肥物质科学研究院 | 2023-09-21 | — | — | WO | disclosed |
| WO-2023173480-A1 | SELECTIVE CSF1R INHIBITOR AND USE THEREOF | 中国科学院合肥物质科学研究院 | 2023-09-21 | — | — | WO | disclosed |