Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 4/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.57 |
| ▸ | BRAF | P15056 | 1/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.57 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 4/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.52 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | AKT2 | P31751 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25403334 | 0.90 | KDR (0.65) | CSF1RKDRBRAFMAPK14TNNI3K | |
| SCHEMBL2847973 | 0.83 | KDR (0.74) | CSF1RKDRBRAFMAPK14TNNI3K | |
| SCHEMBL26272089 | 0.82 | KDR (0.66) | CSF1RKDRBRAFMAPK14TNNI3K | |
| SCHEMBL26271759 | 0.82 | CSF1R (0.75) | CSF1RKDRBRAFRETPDGFRB | |
| SCHEMBL26272705 | 0.79 | CSF1R (0.63) | CSF1RKDRBRAFPDGFRBPDGFRA | |
| SCHEMBL25405250 | 0.79 | CSF1R (0.63) | CSF1RKDRBRAFPDGFRBPDGFRA | |
| SCHEMBL25405811 | 0.77 | KDR (0.81) | CSF1RKDRBRAFMAPK14TNNI3K | |
| SCHEMBL29261085 | 0.77 | TRPA1 (0.66) | CSF1RKDRBRAFMAPK14TNNI3K | |
| SCHEMBL4548909 | 0.76 | KDR (0.79) | CSF1RKDRBRAFMAPK14TNNI3K | |
| SCHEMBL12975650 | 0.76 | NR2E1 (0.55) | CSF1RKDRBRAFMAPK14TNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116789670-A | Selective CSF1R inhibitor and application thereof | 中国科学院合肥物质科学研究院 | 2023-09-22 | — | — | CN | disclosed |
| WO-2023173480-A1 | SELECTIVE CSF1R INHIBITOR AND USE THEREOF | 中国科学院合肥物质科学研究院 | 2023-09-21 | — | — | WO | disclosed |
| WO-2023173480-A1 | SELECTIVE CSF1R INHIBITOR AND USE THEREOF | 中国科学院合肥物质科学研究院 | 2023-09-21 | — | — | WO | disclosed |