Sugi Predict

Sugi Predict / Compounds / SCHEMBL2540372

SCHEMBL2540372

SCHEMBL2540372

COc1ccc(CN(Cc2ccc(N(C)C)cc2)c2ccc3[nH]cnc3c2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ QPCT Q16769 13/20 0.64
▸ MMP12 P39900 1/20 0.45
▸ LMNA P02545 2/20 0.41
▸ MAPT P10636 1/20 0.41
▸ CALM1 P0DP23 1/20 0.41
▸ QPCTL Q9NXS2 2/20 0.40
▸ MEN1 O00255 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ CYP1A2 P05177 1/20 0.39
▸ CHRM2 P08172 1/20 0.39
▸ CYP3A4 P08684 1/20 0.39
▸ HTR1A P08908 1/20 0.39
▸ ADRA2A P08913 1/20 0.39
▸ CYP2D6 P10635 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ DRD1 P21728 1/20 0.39
▸ HTR2A P28223 1/20 0.39
▸ HTR2C P28335 1/20 0.39
▸ SLC6A4 P31645 1/20 0.39
▸ CYP2C19 P33261 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2546223 0.95 QPCT (0.69) QPCTMMP12LMNAMAPTQPCTL
SCHEMBL2546379 0.87 QPCT (0.84) QPCTMMP12LMNAMAPTQPCTL
SCHEMBL2544100 0.86 QPCT (0.72) QPCTMEN1ALDH1A1TSHRCYP2C19
SCHEMBL15267629 0.86 QPCT (0.84) QPCTMMP12CYP1A2CYP3A4CYP2D6
SCHEMBL2544327 0.85 QPCT (0.62) QPCTMMP12MAPTQPCTLMEN1
SCHEMBL2546370 0.83 QPCT (0.83) QPCTMAPTQPCTLMEN1ALDH1A1
SCHEMBL2546550 0.83 QPCT (0.60) QPCTMMP12LMNAMAPTQPCTL
SCHEMBL15267609 0.82 QPCT (0.59) QPCTMMP12LMNAMAPTQPCTL
SCHEMBL2539874 0.82 QPCT (0.82) QPCTMMP12QPCTLSLC6A4SLC6A3
SCHEMBL12230728 0.81 QPCT (0.55) QPCTMMP12QPCTLALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2560953-B1 INHIBITORS OF GLUTAMINYL CYCLASE PROBIODRUG AG (DE) 2016-01-06 — — EP claimed
US-8541596-B2 Inhibitors PROBIODRUG AG (DE) 2013-09-24 — — US claimed
EP-2560953-B1 INHIBITORS OF GLUTAMINYL CYCLASE PROBIODRUG AG (DE) 2016-01-06 — — EP disclosed
EP-2560953-B1 INHIBITORS OF GLUTAMINYL CYCLASE PROBIODRUG AG (DE) 2016-01-06 — — EP disclosed
US-8541596-B2 Inhibitors PROBIODRUG AG (DE) 2013-09-24 — — US disclosed
US-8541596-B2 Inhibitors PROBIODRUG AG (DE) 2013-09-24 — — US disclosed
US-8541596-B2 Inhibitors PROBIODRUG AG (DE) 2013-09-24 — — US disclosed
EP-2560953-A2 NOVEL INHIBITORS Probiodrug AG (DE) 2013-02-27 — — EP disclosed
WO-2011131748-A2 NOVEL INHIBITORS PROBIODRUG AG (DE) 2011-10-27 — — WO disclosed
WO-2011131748-A2 NOVEL INHIBITORS PROBIODRUG AG (DE) 2011-10-27 — — WO disclosed
US-20110262388-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2011-10-27 — — US disclosed
US-20110262388-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2011-10-27 — — US disclosed
US-20110262388-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2011-10-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110262388-A1 NOVEL INHIBITORS GLUL, QPCT, GLS QPCT 2/4885MMP12 3622/4885LMNA 3052/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.