SCHEMBL25410585

SCHEMBL25410585

O=C(Nc1ncnc2c1ccn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1F)c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ ADK P55263 3/20 0.60
▸ SLC29A1 Q99808 1/20 0.52
▸ METTL3 Q86U44 2/20 0.50
▸ METTL14 Q9HCE5 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31167393 1.00 ADK (0.60) ADKSLC29A1METTL3METTL14
SCHEMBL27103047 0.92 ADK (0.50) ADKSLC29A1METTL3METTL14
SCHEMBL24687181 0.92 ADK (0.72) ADKSLC29A1METTL3METTL14
SCHEMBL23023836 0.92 ADK (0.72) ADKSLC29A1METTL3METTL14
SCHEMBL31123791 0.92 ADK (0.72) ADKSLC29A1METTL3METTL14
SCHEMBL23621389 0.85 LMNA (0.60) SLC29A1
SCHEMBL18521420 0.85 LMNA (0.60) SLC29A1
SCHEMBL21625242 0.85 LMNA (0.60) SLC29A1
SCHEMBL21063207 0.85 LMNA (0.60) SLC29A1
SCHEMBL314052 0.85 LMNA (0.60) SLC29A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4489792-A1 PHENYL MALEIMIDE LINKER AGENTS Firefly Bio, Inc. (US) 2025-01-15 — — EP disclosed
US-20240067640-A1 PHENYL MALEIMIDE LINKER AGENTS FIREFLY BIO, INC. 2024-02-29 — — US disclosed
US-20240067640-A1 PHENYL MALEIMIDE LINKER AGENTS FIREFLY BIO, INC. 2024-02-29 — — US disclosed
WO-2023173121-A1 PHENYL MALEIMIDE LINKER AGENTS FIREFLY BIO, INC. (US) 2023-09-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240067640-A1 PHENYL MALEIMIDE LINKER AGENTS TPX2, H1-4, MAPT ADK 3941/4885SLC29A1 268/4885METTL3 2305/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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