Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 4/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | EEF2K | O00418 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1595330 | 1.00 | FFAR1 (0.34) | FFAR1PDPK1CES2CES1UTS2R | |
| SCHEMBL1594372 | 0.88 | FFAR1 (0.36) | FFAR1AKR1C3AKR1C2MEN1KMT2A | |
| SCHEMBL1595345 | 0.82 | FFAR1 (0.32) | FFAR1UTS2RMEN1KMT2ACYP3A4 | |
| SCHEMBL1595344 | 0.82 | FFAR1 (0.32) | FFAR1UTS2RMEN1KMT2ACYP3A4 | |
| SCHEMBL2547936 | 0.82 | FFAR1 (0.32) | FFAR1UTS2RMEN1KMT2ACYP3A4 | |
| SCHEMBL2547934 | 0.82 | FFAR1 (0.32) | FFAR1UTS2RMEN1KMT2ACYP3A4 | |
| SCHEMBL1595009 | 0.81 | FFAR1 (0.38) | FFAR1CES2CES1AKR1C3AKR1C2 | |
| SCHEMBL1596367 | 0.81 | AKR1C3 (0.33) | FFAR1CES2CES1AKR1C3AKR1C2 | |
| SCHEMBL2548060 | 0.79 | AKR1C3 (0.37) | FFAR1PDPK1CES2CES1UTS2R | |
| SCHEMBL1595216 | 0.79 | AKR1C3 (0.37) | FFAR1PDPK1CES2CES1UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263647-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263647-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | TFEB, PCK2, JAK2 | FFAR1 381/4885PDPK1 41/4885CES2 1898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.