Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | GBA1 | P04062 | 3/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | GJB2 | P29033 | 1/20 | 0.44 |
| ▸ | LGALS8 | O00214 | 2/20 | 0.44 |
| ▸ | LGALS3 | P17931 | 2/20 | 0.44 |
| ▸ | LGALS4 | P56470 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25415432 | 0.93 | MAPK1 (0.60) | MAPK1GBA1TNFSLC2A1GJB2 | |
| SCHEMBL25415166 | 0.93 | MAPK1 (0.60) | MAPK1GBA1TNFSLC2A1GJB2 | |
| SCHEMBL25414516 | 0.93 | MAPK1 (0.60) | MAPK1GBA1TNFSLC2A1GJB2 | |
| SCHEMBL5678760 | 0.92 | MAPK1 (0.58) | MAPK1GBA1TNFSLC2A1GJB2 | |
| SCHEMBL25415993 | 0.88 | MAPK1 (0.55) | MAPK1GBA1TNFSLC2A1GJB2 | |
| SCHEMBL25415334 | 0.88 | MAPK1 (0.55) | MAPK1GBA1TNFSLC2A1GJB2 | |
| SCHEMBL25415041 | 0.87 | TNF (0.58) | MAPK1GBA1TNFSLC2A1GJB2 | |
| SCHEMBL10775003 | 0.87 | TNF (0.58) | MAPK1GBA1TNFSLC2A1GJB2 | |
| SCHEMBL546864 | 0.87 | MAPK1 (0.60) | MAPK1GBA1TNFSLC2A1GJB2 | |
| SCHEMBL14747620 | 0.87 | MAPK1 (0.52) | MAPK1GBA1TNFSLC2A1GJB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025233849-A2 | MAPT siRNA AND USES THEREOF | JANSSEN PHARMACEUTICA NV (BE) | 2025-11-13 | — | — | WO | disclosed |
| EP-4493691-A2 | MAPT SIRNA AND USES THEREOF | JANSSEN Pharmaceutica NV (BE) | 2025-01-22 | — | — | EP | disclosed |
| WO-2023175091-A2 | MAPT siRNA AND USES THEREOF | JANSSEN PHARMACEUTICA NV (BE) | 2023-09-21 | — | — | WO | disclosed |