SCHEMBL254258

SCHEMBL254258

CCCCCCCCCCCCCCCCCC(Cl)(Br)I

nearest known ligand 0.41

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GGPS1 O95749 6/20 0.41
TSHR P16473 2/20 0.40
THRB P10828 1/20 0.40
FDPS P14324 10/20 0.39
SMPD1 P17405 2/20 0.39
ALDH1A1 P00352 1/20 0.38
CES2 O00748 1/20 0.34
LPAR1 Q92633 1/20 0.34
LPAR3 Q9UBY5 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5704637 0.79 TSHR (0.44) GGPS1TSHRTHRBFDPSSMPD1
SCHEMBL5136459 0.76
SCHEMBL16970387 0.73 TSHR (0.50) GGPS1TSHRTHRBFDPSSMPD1
SCHEMBL16969619 0.73 TSHR (0.50) GGPS1TSHRTHRBFDPSSMPD1
SCHEMBL7613996 0.73 TSHR (0.50) GGPS1TSHRTHRBFDPSSMPD1
SCHEMBL16969774 0.73 TSHR (0.50) GGPS1TSHRTHRBFDPSSMPD1
SCHEMBL8685667 0.73 TSHR (0.50) GGPS1TSHRTHRBFDPSSMPD1
SCHEMBL9808534 0.73 TSHR (0.50) GGPS1TSHRTHRBFDPSSMPD1
SCHEMBL665460 0.73 TSHR (0.50) GGPS1TSHRTHRBFDPSSMPD1
SCHEMBL16969980 0.73 TSHR (0.50) GGPS1TSHRTHRBFDPSSMPD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230285378-A1 Anti-Viral Compounds ABBVIE INC. (US) 2023-09-14 US disclosed
EP-3438106-A1 ANTI-VIRAL COMPOUNDS AbbVie Ireland Unlimited Company (IE) 2019-02-06 EP disclosed
US-20190015402-A1 Anti-Viral Compounds ABBVIE INC. (US) 2019-01-17 US disclosed
US-10039754-B2 Anti-viral compounds ABBVIE INC. (US) 2018-08-07 US disclosed
US-10028937-B2 Anti-viral compounds ABBVIE INC. (US) 2018-07-24 US disclosed
US-20170157105-A1 Anti-Viral Compounds ABBVIE INC. (US) 2017-06-08 US disclosed
US-20170157104-A1 Anti-Viral Compounds ABBVIE INC. (US) 2017-06-08 US disclosed
EP-2678334-B1 ANTI-VIRAL COMPOUNDS ABBVIE BAHAMAS LTD (BS) 2017-03-22 EP disclosed
US-9586978-B2 Anti-viral compounds ABBVIE INC. (US) 2017-03-07 US disclosed
US-9394279-B2 Anti-viral compounds ABBVIE INC. (US) 2016-07-19 US disclosed
US-20110092415-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2011-04-21 US disclosed
US-20100317568-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2010-12-16 US disclosed
WO-2010144646-A2 ANTI-VIRAL COMPOUNDS ABBOTT LABORATORIES (US) 2010-12-16 WO disclosed
WO-2010120935-A1 ANTI-VIRAL COMPOUNDS ABBOTT LABORATORIES (US) 2010-10-21 WO disclosed
US-20100267634-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2010-10-21 US disclosed
WO-2010075376-A2 ANTI-VIRAL COMPOUNDS ABBOTT LABORATORIES (US) 2010-07-01 WO disclosed
WO-2010075380-A1 ANTI-VIRAL COMPOUNDS ABBOTT LABORATORIES (US) 2010-07-01 WO disclosed
US-20100168384-A1 ANTI-VIRAL COMPOUNDS ABBOTT LABORATORIES (US) 2010-07-01 US disclosed
US-20100168138-A1 Anti-Viral Compounds ABBOTT LABORATORIES (US) 2010-07-01 US disclosed
US-20100160355-A1 Anti-Viral Compounds ABBOTT LABORATORIES (US) 2010-06-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100168138-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS GGPS1 921/4885TSHR 4834/4885THRB 4622/4885
US-20100317568-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS GGPS1 921/4885TSHR 4834/4885THRB 4622/4885
US-20100267634-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS GGPS1 921/4885TSHR 4834/4885THRB 4622/4885
US-10028937-B2 Anti-viral compounds HAVCR2, EIF2AK2, MAVS GGPS1 921/4885TSHR 4834/4885THRB 4622/4885
US-20230285378-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS GGPS1 921/4885TSHR 4834/4885THRB 4622/4885
US-20100168384-A1 ANTI-VIRAL COMPOUNDS HAVCR2, EIF2AK2, MAVS GGPS1 1031/4885TSHR 4804/4885THRB 4558/4885
US-20100160355-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS GGPS1 921/4885TSHR 4834/4885THRB 4622/4885
US-20170157105-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS GGPS1 921/4885TSHR 4834/4885THRB 4622/4885
US-20110092415-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS GGPS1 921/4885TSHR 4834/4885THRB 4622/4885
US-20170157104-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS GGPS1 921/4885TSHR 4834/4885THRB 4622/4885
US-20190015402-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS GGPS1 921/4885TSHR 4834/4885THRB 4622/4885
US-10039754-B2 Anti-viral compounds HAVCR2, EIF2AK2, MAVS GGPS1 921/4885TSHR 4834/4885THRB 4622/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.