Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.48 |
| ▸ | KIF11 | P52732 | 9/20 | 0.44 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25424593 | 0.88 | PDE5A (0.42) | PDE5AKIF11TP53MAPTSMN1; SMN2 | |
| SCHEMBL25422610 | 0.87 | PDE5A (0.52) | PDE5AKIF11HTR2AHTR2CTP53 | |
| SCHEMBL25424553 | 0.86 | PDE5A (0.48) | PDE5AKIF11HTR2AHTR2CTP53 | |
| SCHEMBL25425469 | 0.85 | PDE5A (0.51) | PDE5AKIF11HTR2AHTR2C | |
| SCHEMBL25424470 | 0.83 | PDE5A (0.47) | PDE5AKIF11HTR2AHTR2CTP53 | |
| SCHEMBL25423821 | 0.83 | HTR2C (0.52) | PDE5AKIF11HTR2AHTR2C | |
| SCHEMBL25426941 | 0.82 | PDE5A (0.51) | PDE5AKIF11TP53MAPTSMN1; SMN2 | |
| SCHEMBL25423920 | 0.80 | KIF11 (0.44) | PDE5AKIF11HTR2AHTR2CSIRT1 | |
| SCHEMBL25424049 | 0.78 | PDE5A (0.45) | PDE5ATP53MAPTSMN1; SMN2 | |
| SCHEMBL25425899 | 0.78 | MAPT (0.49) | PDE5AKIF11HTR2AHTR2CTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023130070-A2 | CARBOLINE COMPOUNDS AND USE THEREOF | PTC THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | claimed |