Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 9/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31150480 | 1.00 | SYK (0.42) | SYKPIK3CAALDH1A1HPGDPIK3C3 | |
| SCHEMBL25949040 | 0.75 | ALDH1A1 (0.36) | PIK3CAALDH1A1HPGDHSD11B1KDM4E | |
| SCHEMBL31150453 | 0.72 | AR (0.37) | PIK3CAALDH1A1HPGDHSD11B1KDM4E | |
| SCHEMBL25425906 | 0.72 | AR (0.37) | PIK3CAALDH1A1HPGDHSD11B1KDM4E | |
| SCHEMBL13724767 | 0.72 | SYK (0.49) | SYKALDH1A1PIK3C3CDK2CASP3 | |
| SCHEMBL3550347 | 0.72 | SYK (0.49) | SYKALDH1A1PIK3C3CDK2CASP3 | |
| SCHEMBL1673469 | 0.71 | NUDT1 (0.46) | PIK3C3 | |
| SCHEMBL1444384 | 0.70 | QPCT (0.42) | ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL1444563 | 0.70 | NR3C2 (0.49) | — | |
| SCHEMBL1445163 | 0.70 | DYRK1A (0.43) | ALDH1A1HSD11B1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4466258-A1 | NEW BENZIMIDAZOLE PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2024-11-27 | — | — | EP | disclosed |
| WO-2023139085-A1 | NEW BENZIMIDAZOLE PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2023-07-27 | — | — | WO | disclosed |
| WO-2023139085-A1 | NEW BENZIMIDAZOLE PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2023-07-27 | — | — | WO | disclosed |