Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 4/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | TAS2R8 | Q9NYW2 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26024152 | 0.79 | GRIN1 (0.45) | ADORA2BADORA1ADORA2AL3MBTL1CREBBP | |
| SCHEMBL25431785 | 0.79 | ADORA2A (0.47) | ADORA2BADORA1ADORA2ATAS2R8L3MBTL1 | |
| SCHEMBL25431462 | 0.78 | ADORA2A (0.40) | ADORA2BADORA1ADORA2ATAS2R8L3MBTL1 | |
| SCHEMBL21552996 | 0.72 | ADORA2B (0.48) | ADORA2BADORA1ADORA2ATAS2R8L3MBTL1 | |
| SCHEMBL30719406 | 0.71 | ADORA2A (0.47) | ADORA2BADORA1ADORA2AL3MBTL1ERCC5 | |
| SCHEMBL25561729 | 0.69 | KMT2A (0.59) | L3MBTL1HSP90AA1HSP90AB1NPBWR1MEN1 | |
| SCHEMBL3356524 | 0.69 | ADORA2A (0.47) | ADORA2BADORA1ADORA2AL3MBTL1HSP90AA1 | |
| SCHEMBL17801147 | 0.68 | JAK2 (0.43) | ADORA2BADORA1ADORA2AL3MBTL1 | |
| SCHEMBL27901467 | 0.68 | L3MBTL1 (0.53) | ADORA2BADORA1ADORA2AL3MBTL1HSP90AA1 | |
| SCHEMBL17801229 | 0.67 | JAK2 (0.42) | ADORA2BADORA1ADORA2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4476204-A1 | COMPOUNDS HAVING A T-STRUCTURE FORMED BY AT LEAST FOUR CYCLES FOR USE IN THE TREATMENT OF CANCER AND OTHER INDICATIONS | Theras, Inc. (US) | 2024-12-18 | — | — | EP | disclosed |
| CN-118946555-A | Compounds having T-structures formed by at least four rings for use in the treatment of cancer and other indications | 瑟拉斯有限公司 | 2024-11-12 | — | — | CN | disclosed |
| WO-2023154282-A1 | COMPOUNDS HAVING A T-STRUCTURE FORMED BY AT LEAST FOUR CYCLES FOR USE IN THE TREATMENT OF CANCER AND OTHER INDICATIONS | THERAS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |
| WO-2023154282-A1 | COMPOUNDS HAVING A T-STRUCTURE FORMED BY AT LEAST FOUR CYCLES FOR USE IN THE TREATMENT OF CANCER AND OTHER INDICATIONS | THERAS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |