Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | TDO2 | P48775 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25432923 | 0.80 | — | — | |
| SCHEMBL25436669 | 0.77 | IDO1 (0.33) | METAP2IDO1TDO2 | |
| SCHEMBL25435644 | 0.75 | PARG (0.31) | — | |
| SCHEMBL25439477 | 0.72 | IDO1 (0.30) | IDO1TDO2 | |
| SCHEMBL30621735 | 0.69 | CA1 (0.42) | METAP2IDO1TDO2 | |
| SCHEMBL30485728 | 0.65 | CYP3A4 (0.47) | IDO1TDO2 | |
| SCHEMBL5767535 | 0.65 | KDM4E (0.44) | — | |
| SCHEMBL30485698 | 0.60 | MAPT (0.55) | METAP2 | |
| SCHEMBL23124425 | 0.60 | MAPT (0.55) | METAP2 | |
| SCHEMBL6643829 | 0.59 | CA2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154913-A1 | INHIBITORS OF PARG | ARASE THERAPEUTICS INC. (US) | 2023-08-17 | — | — | WO | claimed |
| EP-4479387-A1 | INHIBITORS OF PARG | ARase Therapeutics Inc. (US) | 2024-12-25 | — | — | EP | disclosed |
| WO-2023154913-A1 | INHIBITORS OF PARG | ARASE THERAPEUTICS INC. (US) | 2023-08-17 | — | — | WO | disclosed |