Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NOS1 | P29475 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.50 |
| ▸ | METAP2 | P50579 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CASP6 | P55212 | 2/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23124425 | 1.00 | MAPT (0.55) | MAPTMEN1KMT2AKDM4EPKM | |
| SCHEMBL31647068 | 0.86 | KDR (0.57) | MAPTMEN1KMT2AKDM4ENOS1 | |
| SCHEMBL5220947 | 0.86 | KDR (0.57) | MAPTMEN1KMT2AKDM4ENOS1 | |
| SCHEMBL6081930 | 0.83 | KDR (0.59) | MAPTMEN1KMT2AKDM4EHTT | |
| SCHEMBL8012676 | 0.82 | NOS1 (0.51) | MAPTMEN1KMT2AKDM4EPKM | |
| SCHEMBL1076913 | 0.82 | MEN1 (0.55) | MAPTMEN1KMT2AKDM4EPKM | |
| SCHEMBL31475220 | 0.82 | NOS1 (0.51) | MAPTMEN1KMT2AKDM4EPKM | |
| SCHEMBL4654871 | 0.82 | NOS1 (0.51) | MAPTMEN1KMT2AKDM4EPKM | |
| SCHEMBL17824793 | 0.78 | ALDH1A1 (0.50) | MAPTMEN1KMT2AKDM4EPKM | |
| SCHEMBL25512612 | 0.78 | MEN1 (0.48) | MAPTMEN1KMT2AKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025229549-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS INHIBITORS OF PARG | SATYARX PHARMA INNOVATIONS PVT LTD (IN) | 2025-11-06 | — | — | WO | claimed |
| WO-2025229549-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS INHIBITORS OF PARG | SATYARX PHARMA INNOVATIONS PVT LTD (IN) | 2025-11-06 | — | — | WO | disclosed |
| WO-2025072544-A1 | SULFONAMINO INDAZOLE COMPOUNDS AS INHIBITORS OF PARG | IDEAYA BIOSCIENCES, INC. (US) | 2025-04-03 | — | — | WO | disclosed |
| EP-4479387-A1 | INHIBITORS OF PARG | ARase Therapeutics Inc. (US) | 2024-12-25 | — | — | EP | disclosed |
| CN-118459452-B | PolyADP ribose hydrolase inhibitor and application thereof | 苏州国匡医药科技有限公司 | 2024-10-25 | — | — | CN | disclosed |
| CN-118459452-A | PolyADP ribose hydrolase inhibitor and application thereof | 苏州国匡医药科技有限公司 | 2024-08-09 | — | — | CN | disclosed |
| WO-2023154913-A1 | INHIBITORS OF PARG | ARASE THERAPEUTICS INC. (US) | 2023-08-17 | — | — | WO | disclosed |