Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 4/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 3/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.32 |
| ▸ | KAT5 | Q92993 | 2/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | KAT7 | O95251 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25435054 | 1.00 | MC4R (0.36) | MC4RPDE10AITKKAT8KAT6A | |
| SCHEMBL31421670 | 0.87 | KAT8 (0.35) | MC4RPDE10AKAT8KAT6AKAT5 | |
| SCHEMBL31421678 | 0.87 | KAT8 (0.35) | MC4RPDE10AKAT8KAT6AKAT5 | |
| SCHEMBL25436200 | 0.85 | MC4R (0.51) | MC4RKCNH2GABRA1GABRG2GABRB3 | |
| SCHEMBL25422383 | 0.85 | MC4R (0.51) | MC4RKCNH2GABRA1GABRG2GABRB3 | |
| SCHEMBL25435510 | 0.78 | MC4R (0.52) | MC4RPDE10AITKHCRTR1HCRTR2 | |
| Hydrochloric Acid SCHEMBL30996533 | 0.76 | GABRA1 (0.33) | MC4RHCRTR1HCRTR2KCNH2GABRA1 | |
| Hydrochloric Acid SCHEMBL30996535 | 0.76 | GABRA1 (0.33) | MC4RHCRTR1HCRTR2KCNH2GABRA1 | |
| SCHEMBL31687281 | 0.71 | AXL (0.33) | MC4R | |
| SCHEMBL31666921 | 0.71 | MC4R (0.48) | MC4RPDE10AITKHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023105387-A1 | MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | PFIZER INC. (US) | 2023-06-15 | — | — | WO | disclosed |