Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 11/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31666921 | 0.87 | MC4R (0.48) | MC4RKCNH2KDM5APDE10AITK | |
| SCHEMBL31421674 | 0.87 | MC4R (0.48) | MC4RKCNH2 | |
| SCHEMBL31666910 | 0.83 | MC4R (0.46) | MC4RKCNH2KDM5APDE10AITK | |
| SCHEMBL25421659 | 0.81 | MC4R (0.49) | MC4RKCNH2KDM5ACCNKCDK12 | |
| SCHEMBL31666901 | 0.81 | MC4R (0.56) | MC4RKCNH2 | |
| SCHEMBL25278377 | 0.81 | MC4R (0.59) | MC4RKCNH2KDM5ACCNKCDK12 | |
| SCHEMBL31666903 | 0.80 | MC4R (0.55) | MC4RKCNH2NOS3NOS1NOS2 | |
| SCHEMBL25421249 | 0.80 | MC4R (0.53) | MC4RKCNH2 | |
| SCHEMBL25435054 | 0.78 | MC4R (0.36) | MC4RKCNH2PDE10AITKHCRTR1 | |
| SCHEMBL25435323 | 0.78 | MC4R (0.36) | MC4RKCNH2PDE10AITKHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023105387-A1 | MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | PFIZER INC. (US) | 2023-06-15 | — | — | WO | disclosed |