Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 10/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | NOS2 | P35228 | 2/20 | 0.45 |
| ▸ | KDM5A | P29375 | 1/20 | 0.42 |
| ▸ | CCNK | O75909 | 3/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30833316 | 0.86 | MC4R (0.57) | MC4RKCNH2NOS2BTK | |
| SCHEMBL30458036 | 0.86 | MC4R (0.57) | MC4RKCNH2NOS2BTK | |
| SCHEMBL25230080 | 0.82 | MC4R (0.49) | MC4RKCNH2CCNKCDK12JAK2 | |
| SCHEMBL25420312 | 0.81 | MC4R (0.55) | MC4RKCNH2CCNKCDK12BTK | |
| SCHEMBL25435510 | 0.81 | MC4R (0.52) | MC4RKCNH2NOS2KDM5ACCNK | |
| SCHEMBL25225248 | 0.80 | MC4R (0.46) | MC4RKCNH2NOS2CCNKCDK12 | |
| SCHEMBL25422750 | 0.80 | MC4R (0.67) | MC4RKCNH2CCNKCDK12BTK | |
| SCHEMBL25277175 | 0.80 | MC4R (0.51) | MC4RKCNH2 | |
| SCHEMBL25437281 | 0.78 | MC4R (0.55) | MC4RKCNH2KDM5ACCNKCDK12 | |
| SCHEMBL25272411 | 0.77 | OPRM1 (0.55) | NOS2KDM5ACCNKCDK12JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023105387-A1 | MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | PFIZER INC. (US) | 2023-06-15 | — | — | WO | disclosed |