Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 8/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.48 |
| ▸ | STAT6 | P42226 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22261068 | 0.89 | JAK2 (0.59) | NTRK1RPS6KB1AURKAAURKBJAK2 | |
| SCHEMBL4188524 | 0.88 | CSNK2A2 (0.51) | KDM5AKDM4CKDM5BRPS6KB1JAK3 | |
| Hydrochloric Acid SCHEMBL4178767 | 0.87 | CSNK2A2 (0.50) | KDM5AKDM4CKDM5BRPS6KB1JAK3 | |
| SCHEMBL25435346 | 0.85 | P4HTM (0.51) | RPS6KB1AURKAJAK3STAT6ADORA3 | |
| SCHEMBL28713125 | 0.83 | NTRK1 (0.62) | NTRK1CCNT1 | |
| SCHEMBL29392704 | 0.83 | NTRK1 (0.62) | NTRK1CCNT1 | |
| SCHEMBL25435320 | 0.83 | VNN1 (0.54) | JAK2JAK3 | |
| SCHEMBL15584955 | 0.80 | NTRK1 (0.50) | NTRK1AURKAAURKBJAK2JAK3 | |
| SCHEMBL19675773 | 0.80 | NTRK1 (0.51) | NTRK1AURKAAURKBJAK2JAK3 | |
| SCHEMBL29608147 | 0.80 | NTRK1 (0.51) | NTRK1AURKAAURKBJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3686197-B1 | 2-SUBSTITUTED PYRAZOLE AMINO-4-SUBSTITUTED AMINO-5-PYRIMIDINE FORMAMIDE COMPOUND, COMPOSITION, AND APPLICATION THEREOF | BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN) | 2023-06-21 | — | — | EP | disclosed |