Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | DGKA | P23743 | 2/20 | 0.33 |
| ▸ | DGKZ | Q13574 | 2/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26925729 | 0.89 | DGKA (0.38) | DPP8MAPK14SIGMAR1OPRD1DGKA | |
| SCHEMBL21831531 | 0.89 | DGKA (0.38) | DPP8MAPK14SIGMAR1OPRD1DGKA | |
| SCHEMBL21910729 | 0.87 | TACR1 (0.38) | DPP8MAPK14DGKADGKZ | |
| SCHEMBL26925710 | 0.87 | DPP8 (0.39) | DPP8MAPK14KDM4ECYP1A2CYP3A4 | |
| SCHEMBL21831112 | 0.86 | MAPK14 (0.37) | DPP8MAPK14SIGMAR1DGKADGKZ | |
| SCHEMBL21831875 | 0.85 | DPP8 (0.39) | DPP8MAPK14SIGMAR1DGKADGKZ | |
| SCHEMBL21831052 | 0.85 | DPP8 (0.39) | DPP8MAPK14SIGMAR1DGKADGKZ | |
| SCHEMBL21831267 | 0.84 | DPP8 (0.41) | DPP8MAPK14SIGMAR1SLC6A9 | |
| SCHEMBL21831105 | 0.82 | DGKA (0.42) | DPP8SIGMAR1CYP2C9CYP2C19OPRD1 | |
| SCHEMBL26926180 | 0.82 | DGKZ (0.43) | CYP2C9CYP2C19DGKADGKZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814348-B9 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-11-01 | — | — | EP | disclosed |
| EP-3814348-B1 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-08-02 | — | — | EP | disclosed |