Known targets — ChEMBL curated mechanism
ADRM1PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMA8PSMB1PSMB10PSMB11PSMB2PSMB3PSMB4PSMB5PSMB6PSMB7PSMB8PSMB9PSMC1PSMC2PSMC3PSMC4PSMC5PSMC6PSMD1PSMD11PSMD12PSMD13PSMD14PSMD2PSMD3PSMD4PSMD6PSMD7PSMD8SEM1
The experimentally established mechanism targets of Carfilzomib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 known ✓ | P28074 | 17/20 | 1.00 |
| ▸ | PSMB9 known ✓ | P28065 | 3/20 | 1.00 |
| ▸ | PSMB8 known ✓ | P28062 | 3/20 | 1.00 |
| ▸ | PSMB10 known ✓ | P40306 | 3/20 | 1.00 |
| ▸ | PSMB2 known ✓ | P49721 | 3/20 | 1.00 |
| ▸ | PSMB11 known ✓ | A5LHX3 | 1/20 | 1.00 |
| ▸ | PSMD11 known ✓ | O00231 | 1/20 | 1.00 |
| ▸ | PSMD12 known ✓ | O00232 | 1/20 | 1.00 |
| ▸ | PSMD14 known ✓ | O00487 | 1/20 | 1.00 |
| ▸ | PSMA7 known ✓ | O14818 | 1/20 | 1.00 |
| ▸ | PSMD3 known ✓ | O43242 | 1/20 | 1.00 |
| ▸ | PSMC3 known ✓ | P17980 | 1/20 | 1.00 |
| ▸ | PSMB1 known ✓ | P20618 | 1/20 | 1.00 |
| ▸ | PSMA1 known ✓ | P25786 | 1/20 | 1.00 |
| ▸ | PSMA2 known ✓ | P25787 | 1/20 | 1.00 |
| ▸ | PSMA3 known ✓ | P25788 | 1/20 | 1.00 |
| ▸ | PSMA4 known ✓ | P25789 | 1/20 | 1.00 |
| ▸ | PSMA5 known ✓ | P28066 | 1/20 | 1.00 |
| ▸ | PSMB4 known ✓ | P28070 | 1/20 | 1.00 |
| ▸ | PSMB6 known ✓ | P28072 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carfilzomib SCHEMBL21036021 | 1.00 | PSMB5 (1.00) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| Carfilzomib SCHEMBL21036176 | 1.00 | PSMB5 (1.00) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| Carfilzomib SCHEMBL21035430 | 1.00 | PSMB5 (1.00) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| Carfilzomib SCHEMBL21036163 | 1.00 | PSMB5 (1.00) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| Carfilzomib SCHEMBL23616374 | 1.00 | PSMB5 (1.00) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| Carfilzomib SCHEMBL21036204 | 1.00 | PSMB5 (1.00) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| Carfilzomib SCHEMBL24140134 | 1.00 | PSMB5 (1.00) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| Carfilzomib SCHEMBL21367423 | 1.00 | PSMB5 (1.00) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| Carfilzomib SCHEMBL20825319 | 1.00 | PSMB5 (1.00) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| Carfilzomib SCHEMBL21350259 | 1.00 | PSMB5 (1.00) | PSMB5PSMB9PSMB8PSMB10PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240277794-A1 | ONCOLYTIC VIRUSES FOR MODIFIED MHC EXPRESSION | KALIVIR IMMUNOTHERAPEUTICS, INC. | 2024-08-22 | — | — | US | disclosed |
| US-12016893-B2 | Oncolytic viruses for modified MHC expression | KALIVIR IMMUNOTHERAPEUTICS, INC. (US) | 2024-06-25 | — | — | US | disclosed |
| US-11963990-B2 | Oncolytic viruses for modified MHC expression | KALIVIR IMMUNOTHERAPEUTICS, INC. (US) | 2024-04-23 | — | — | US | disclosed |
| US-20230338445-A1 | ONCOLYTIC VIRUSES FOR MODIFIED MHC EXPRESSION | KALIVIR IMMUNOTHERAPEUTICS, INC. | 2023-10-26 | — | — | US | disclosed |
| US-20230263846-A1 | ONCOLYTIC VIRUSES FOR MODIFIED MHC EXPRESSION | KALIVIR IMMUNOTHERAPEUTICS, INC. | 2023-08-24 | — | — | US | disclosed |