Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAT2A | P31153 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25439587 | 0.90 | PTPN11 (0.54) | PTPN11MAPTMAT2APOLBNOTUM | |
| SCHEMBL30421525 | 0.90 | PTPN11 (0.54) | PTPN11MAPTMAT2APOLBNOTUM | |
| SCHEMBL31485521 | 0.89 | MAT2A (0.47) | PTPN11MAPTMAT2APOLBNOTUM | |
| Hydrochloric Acid SCHEMBL30422152 | 0.88 | MAT2A (0.47) | PTPN11MAPTMAT2APOLBNOTUM | |
| Hydrochloric Acid SCHEMBL25213549 | 0.88 | MAT2A (0.47) | PTPN11MAPTMAT2APOLBNOTUM | |
| SCHEMBL31148425 | 0.85 | MAT2A (0.47) | PTPN11MAPTMAT2APOLBNOTUM | |
| SCHEMBL25210578 | 0.85 | PTPN11 (0.45) | PTPN11MAPTPOLBENPP2 | |
| SCHEMBL25421374 | 0.84 | MAT2A (0.45) | PTPN11MAPTMAT2APOLBNOTUM | |
| SCHEMBL25260159 | 0.83 | MAT2A (0.45) | PTPN11MAPTMAT2APOLBNOTUM | |
| SCHEMBL25245582 | 0.83 | MAT2A (0.45) | PTPN11MAPTMAT2APOLBNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102231-A1 | 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND METHODS OF USING THE SAME | RGENTA THERAPEUTICS, INC. (US) | 2023-06-08 | — | — | WO | disclosed |