Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 2/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | CDK9 | P50750 | 2/20 | 0.45 |
| ▸ | TTK | P33981 | 5/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | FYN | P06241 | 2/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.36 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22123511 | 0.89 | PTK6 (0.41) | CCNT1CCNA2CDK2CDK9ALK | |
| SCHEMBL22124749 | 0.89 | CDK2 (0.36) | CCNT1CCNA2CDK2CDK9TTK | |
| SCHEMBL22124796 | 0.87 | CDK2 (0.35) | CCNT1CCNA2CDK2CDK9TTK | |
| SCHEMBL30385860 | 0.87 | CDK2 (0.35) | CCNT1CCNA2CDK2CDK9TTK | |
| Trifluoroacetic Acid SCHEMBL22123848 | 0.85 | PTK6 (0.38) | CCNT1CCNA2CDK2CDK9TTK | |
| SCHEMBL22123810 | 0.83 | TTK (0.40) | CDK2TTKBRAF | |
| SCHEMBL22123165 | 0.83 | TTK (0.42) | CDK2TTKBTKJAK3AURKA | |
| SCHEMBL22156708 | 0.82 | EGFR (0.38) | ALKAURKA | |
| SCHEMBL22124815 | 0.82 | TTK (0.39) | CDK2TTKBRAF | |
| SCHEMBL22124871 | 0.82 | SYK (0.39) | TTKBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898630-B1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2023-05-10 | — | — | EP | disclosed |