Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | CHAT | P28329 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 4/20 | 0.46 |
| ▸ | CA2 | P00918 | 4/20 | 0.46 |
| ▸ | CA12 | O43570 | 3/20 | 0.46 |
| ▸ | CA9 | Q16790 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2544406 | 1.00 | LMNA (0.50) | LMNAL3MBTL1DHODHCHATMAPT | |
| SCHEMBL11781793 | 0.84 | CHEK1 (0.44) | LMNAL3MBTL1DHODHCHATMAPT | |
| SCHEMBL10799444 | 0.83 | DHODH (0.71) | LMNAL3MBTL1DHODHCHATMAPT | |
| SCHEMBL12417102 | 0.83 | DHODH (0.71) | LMNAL3MBTL1DHODHCHATMAPT | |
| SCHEMBL5363618 | 0.83 | DHODH (0.71) | LMNAL3MBTL1DHODHCHATMAPT | |
| SCHEMBL12633216 | 0.82 | LMNA (0.59) | LMNAL3MBTL1DHODHCHATMAPT | |
| SCHEMBL1870853 | 0.82 | LMNA (0.59) | LMNAL3MBTL1DHODHCHATMAPT | |
| SCHEMBL1710167 | 0.82 | LMNA (0.59) | LMNAL3MBTL1DHODHCHATMAPT | |
| SCHEMBL22299852 | 0.81 | MEN1 (0.50) | LMNAL3MBTL1DHODHCHATMAPT | |
| SCHEMBL28320760 | 0.81 | DHODH (0.59) | LMNAL3MBTL1DHODHCHATMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2014281-A1 | Use of inhibitors of sirtuins and/or ampk for the preparation of a medicament for the treatment of polyalanine diseases. | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2009-01-14 | — | — | EP | claimed |
| WO-2008155390-A2 | USE OF INHIBITORS OF SIRTUINS AND/OR AMPK FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF POLYALANINE DISEASES. | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2008-12-24 | — | — | WO | claimed |
| US-9168316-B2 | Methods for treating obesity | GU YANSONG (US) | 2015-10-27 | — | — | US | disclosed |
| US-8980852-B2 | Methods for treating obesity | GU YANSONG (US) | 2015-03-17 | — | — | US | disclosed |
| US-20140322136-A1 | METHODS FOR TREATING OBESITY | GU YANSONG (US) | 2014-10-30 | — | — | US | disclosed |
| US-20110262362-A1 | METHODS FOR TREATING OBESITY | GU YANSONG | 2011-10-27 | — | — | US | disclosed |
| EP-2014281-A1 | Use of inhibitors of sirtuins and/or ampk for the preparation of a medicament for the treatment of polyalanine diseases. | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2009-01-14 | — | — | EP | disclosed |
| WO-2008155390-A2 | USE OF INHIBITORS OF SIRTUINS AND/OR AMPK FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF POLYALANINE DISEASES. | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2008-12-24 | — | — | WO | disclosed |