SCHEMBL25446362

SCHEMBL25446362

C=[N+]1CCC(C(=O)NCCOCCOc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1

nearest known ligand 0.49

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
STAT3 P40763 4/20 0.49
CRBN Q96SW2 10/20 0.49
DDB1 Q16531 9/20 0.49
MAPT P10636 4/20 0.46
IRAK4 Q9NWZ3 1/20 0.43
EGFR P00533 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25446263 0.90 STAT3 (0.52) STAT3CRBNDDB1MAPTIRAK4
Formic Acid SCHEMBL30440705 0.87 STAT3 (0.49) STAT3CRBNDDB1MAPTIRAK4
Hydrochloric Acid SCHEMBL30441024 0.84 CRBN (0.54) STAT3CRBNDDB1
Formic Acid SCHEMBL30440658 0.82 CRBN (0.52) STAT3CRBNDDB1
SCHEMBL22276609 0.81 CRBN (0.70) STAT3CRBNDDB1MAPT
SCHEMBL27208479 0.81 CRBN (0.53) STAT3CRBNDDB1MAPT
SCHEMBL21771120 0.81 MAPT (0.55) CRBNDDB1MAPT
SCHEMBL21472007 0.81 MAPT (0.55) CRBNDDB1MAPT
SCHEMBL25937409 0.81 MAPT (0.55) CRBNDDB1MAPT
SCHEMBL25937530 0.81 MAPT (0.55) CRBNDDB1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023081476-A1 METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION RANOK THERAPEUTICS (HANGZHOU) CO. LTD. (CN) 2023-05-11 WO disclosed