Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 9/20 | 0.56 |
| ▸ | CHRNB4 | P30926 | 8/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.48 |
| ▸ | CHRNB1 | P11230 | 5/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.48 |
| ▸ | CHRNB3 | Q05901 | 5/20 | 0.48 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2544681 | 1.00 | METAP2 (0.56) | METAP2CHRNB4CHRNA3CHRNB1CHRNB2 | |
| SCHEMBL2542524 | 0.91 | METAP2 (0.55) | METAP2CHRNB4CHRNA3CHRNB1CHRNB2 | |
| SCHEMBL2542532 | 0.91 | METAP2 (0.55) | METAP2CHRNB4CHRNA3CHRNB1CHRNB2 | |
| SCHEMBL2200916 | 0.91 | METAP2 (0.56) | METAP2CHRNB4CHRNA3CHRNB1CHRNB2 | |
| SCHEMBL3602228 | 0.91 | METAP2 (0.56) | METAP2CHRNB4CHRNA3CHRNB1CHRNB2 | |
| SCHEMBL2200911 | 0.91 | METAP2 (0.56) | METAP2CHRNB4CHRNA3CHRNB1CHRNB2 | |
| SCHEMBL2198675 | 0.87 | METAP2 (0.73) | METAP2CHRNB4CHRNA3 | |
| SCHEMBL2198683 | 0.87 | METAP2 (0.73) | METAP2CHRNB4CHRNA3 | |
| SCHEMBL2546885 | 0.84 | METAP2 (0.55) | METAP2FFAR2 | |
| SCHEMBL2546881 | 0.84 | METAP2 (0.55) | METAP2FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2288351-B1 | NOVEL PYRROLIDONE DERIVATIVES FOR USE AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2018-08-08 | — | — | EP | claimed |
| US-8846694-B2 | Pyrrolidone derivatives for use as MetAP-2 inhibitors | MERCK PATENT GMBH (DE) | 2014-09-30 | — | — | US | claimed |
| US-20110263561-A1 | Novel pyrrolidone derivatives for use as MetAP-2 inhibitors | MERCK PATENT GMBH (DE) | 2011-10-27 | — | — | US | claimed |
| EP-2288351-B1 | NOVEL PYRROLIDONE DERIVATIVES FOR USE AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2018-08-08 | — | — | EP | disclosed |
| EP-2288351-B1 | NOVEL PYRROLIDONE DERIVATIVES FOR USE AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2018-08-08 | — | — | EP | disclosed |
| US-8846694-B2 | Pyrrolidone derivatives for use as MetAP-2 inhibitors | MERCK PATENT GMBH (DE) | 2014-09-30 | — | — | US | disclosed |
| US-8846694-B2 | Pyrrolidone derivatives for use as MetAP-2 inhibitors | MERCK PATENT GMBH (DE) | 2014-09-30 | — | — | US | disclosed |
| US-8846694-B2 | Pyrrolidone derivatives for use as MetAP-2 inhibitors | MERCK PATENT GMBH (DE) | 2014-09-30 | — | — | US | disclosed |
| US-20110263561-A1 | Novel pyrrolidone derivatives for use as MetAP-2 inhibitors | MERCK PATENT GMBH (DE) | 2011-10-27 | — | — | US | disclosed |
| US-20110263561-A1 | Novel pyrrolidone derivatives for use as MetAP-2 inhibitors | MERCK PATENT GMBH (DE) | 2011-10-27 | — | — | US | disclosed |
| US-20110263561-A1 | Novel pyrrolidone derivatives for use as MetAP-2 inhibitors | MERCK PATENT GMBH (DE) | 2011-10-27 | — | — | US | disclosed |
| WO-2010003475-A2 | NOVEL PYRROLIDONE DERIVATIVES FOR USE AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2010-01-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263561-A1 | Novel pyrrolidone derivatives for use as MetAP-2 inhibitors | METAP2, METAP1, ENPEP | METAP2 1/4885CHRNB4 4808/4885CHRNA3 4757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.