Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.55 |
| ▸ | ULK1 | O75385 | 3/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | ROS1 | P08922 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | FER | P16591 | 1/20 | 0.49 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.49 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24179119 | 0.93 | EGFR (0.64) | EGFRJAK2CHEK1AURKACCNT1 | |
| SCHEMBL24179405 | 0.91 | EGFR (0.57) | EGFRJAK2CHEK1AURKACCNT1 | |
| SCHEMBL31291051 | 0.91 | EGFR (0.57) | EGFRJAK2CHEK1AURKACCNT1 | |
| SCHEMBL24178905 | 0.88 | EGFR (0.65) | EGFRJAK2CHEK1AURKACCNT1 | |
| SCHEMBL30216900 | 0.86 | EGFR (0.67) | EGFRJAK2CHEK1AURKACCNT1 | |
| SCHEMBL25449097 | 0.86 | EGFR (0.67) | EGFRJAK2CHEK1AURKACCNT1 | |
| SCHEMBL24179098 | 0.86 | EGFR (0.62) | EGFRJAK2CHEK1AURKACCNT1 | |
| SCHEMBL24178916 | 0.83 | EGFR (0.48) | EGFRULK1JAK2CHEK1AURKA | |
| SCHEMBL23172594 | 0.82 | ULK1 (0.46) | EGFRULK1JAK2MAPK8BTK | |
| SCHEMBL25450025 | 0.81 | EGFR (0.60) | EGFRJAK2CHEK1AURKACCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4177258-A1 | ARYLPHOSPHINE OXIDE COMPOUNDS AND USE THEREOF | Chengdu Di'Ao Jiuhong Pharmaceutical Factory (CN) | 2023-05-10 | — | — | EP | disclosed |