Known targets — ChEMBL curated mechanism
GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3B
The experimentally established mechanism targets of Memantine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 known ✓ | Q05586 | 10/20 | 1.00 |
| ▸ | GRIN2A known ✓ | Q12879 | 10/20 | 1.00 |
| ▸ | GRIN2D known ✓ | O15399 | 9/20 | 0.95 |
| ▸ | GRIN3B known ✓ | O60391 | 9/20 | 0.95 |
| ▸ | GRIN2B known ✓ | Q13224 | 9/20 | 0.95 |
| ▸ | GRIN2C known ✓ | Q14957 | 9/20 | 0.95 |
| ▸ | GRIN3A known ✓ | Q8TCU5 | 9/20 | 0.95 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.95 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.95 |
| ▸ | HTT | P42858 | 2/20 | 0.95 |
| ▸ | ESR1 | P03372 | 1/20 | 0.95 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.95 |
| ▸ | ACHE | P22303 | 1/20 | 0.95 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.95 |
| ▸ | MTOR | P42345 | 1/20 | 0.95 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.95 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Memantine SCHEMBL27711131 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL3053 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL31328273 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL6368832 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL5011429 | 0.98 | GRIN1 (0.95) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL28416563 | 0.98 | GRIN1 (0.95) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL23327176 | 0.97 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL8126868 | 0.97 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL2688 | 0.97 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL2689 | 0.97 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150328147-A1 | METHOD FOR INTRODUCING BIOLOGICALLY ACTIVE SUBSTANCES INTO THE BRAIN | BBU-VITA CORP. (VG) | 2015-11-19 | — | — | US | claimed |
| CN-112494509-A | Composition for preventing and treating Alzheimer's disease and application thereof | 南京生命原健康科技有限公司 | 2021-03-16 | — | — | CN | disclosed |
| CN-103800306-B | Memantine oral membrane and preparation method thereof | 重庆医药工业研究院有限责任公司 | 2020-06-19 | — | — | CN | disclosed |
| EP-3156064-B1 | APPLICATION OF YB-1 PROTEIN AND FRAGMENTS THEREOF FOR PREPARING MEDICINAL AGENTS IN TREATING ALZHEIMER'S DISEASE | INSTITUTE OF PROTEIN RES RUSSIAN ACADEMY OF SCIENCES (RU) | 2019-11-20 | — | — | EP | disclosed |
| US-10143722-B2 | Application of YB-1 protein and fragments thereof for preparing medicinal agents in treating alzheimer's disease | DUPONT, MARIA (DE) | 2018-12-04 | — | — | US | disclosed |
| EP-3156064-A2 | APPLICATION OF YB-1 PROTEIN AND FRAGMENTS THEREOF FOR PREPARING MEDICINAL AGENTS IN TREATING ALZHEIMER'S DISEASE | Institute Of Protein Research Russian Academy Of Sciences (RU) | 2017-04-19 | — | — | EP | disclosed |
| US-20170095435-A1 | AGENT FOR THE TREATMENT AND PREVENTION OF AUTISM SPECTRUM DISORDERS | ZAO ALMAZ PHARM (RU) | 2017-04-06 | — | — | US | disclosed |
| EP-3150231-A1 | AGENT FOR THE TREATMENT AND PREVENTION OF AUTISM SPECTRUM DISORDERS | ZAO "ALMAZ PHARM" (RU) | 2017-04-05 | — | — | EP | disclosed |
| US-20160331806-A1 | APPLICATION OF YB-1 PROTEIN AND FRAGMENTS THEREOF FOR PREPARING MEDICINAL AGENTS IN TREATING ALZHEIMER'S DISEASE | DUPONT, MARIA (DE) | 2016-11-17 | — | — | US | disclosed |
| US-9101451-B2 | Method for correcting pathological configurations of segments of the lower extremities and device for realizing same | Zakrytoe Aktsionernoe Obschestvo Nauchno-Proizvodstvenny Tsentr “Ogonek” (RU) | 2015-08-11 | — | — | US | disclosed |
| US-6255348-B1 | AIDS THERAPY | MERZ + CO. GMBH & CO. (DE) | 2001-07-03 | — | — | US | disclosed |
| US-6172116-B1 | NEUTROPHIL ACTIVATION; TREATING AUTOIMMUNE DISEASES | MERZ + CO. GMBH & CO. (DE) | 2001-01-09 | — | — | US | disclosed |
| US-6066652-A | Method for treating diseases of the inner ear using adamantane derivatives | TINNITUS FORSCHUNGS-UND ENTWICKLUNGS GMBH (DE) | 2000-05-23 | — | — | US | disclosed |
| CN-1224366-A | Pharmaceutical administration form | MUELLER D (DE) | 1999-07-28 | — | — | CN | disclosed |
| CN-1194581-A | Use of adamantan derivatives for treating diseases of inner ear | TIANLITUS RESEARCH AND DEV CO (DE) | 1998-09-30 | — | — | CN | disclosed |
| EP-0845984-A1 | USE OF AMINOADAMANTANE COMPOUNDS AS IMMUNOREGULATORS | MERZ + CO. GmbH & Co. (DE) | 1998-06-10 | — | — | EP | disclosed |
| EP-0834310-A1 | Use of adamantin-derivatives for the treatment of internal-ear-diseases | Zenner, Hans Peter, Prof. Dr. med. (DE) | 1998-04-08 | — | — | EP | disclosed |
| EP-0759295-B1 | Use of adamantan derivatives for the treatment of tinnitus | ZENNER HANS PETER PROF DR MED (DE) | 1998-03-04 | — | — | EP | disclosed |
| WO-1997007791-A1 | USE OF AMINOADAMANTANE COMPOUNDS AS IMMUNOREGULATORS | MERZ + CO. GMBH & CO. (DE) | 1997-03-06 | — | — | WO | disclosed |
| EP-0759295-A1 | Use of adamantan derivatives for the treatment of internal ear diseases | Zenner, Hans Peter, Prof. Dr. med. (DE) | 1997-02-26 | — | — | EP | disclosed |