Known targets — ChEMBL curated mechanism
GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3B
The experimentally established mechanism targets of Memantine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 known ✓ | Q05586 | 8/20 | 0.95 |
| ▸ | GRIN2A known ✓ | Q12879 | 8/20 | 0.95 |
| ▸ | GRIN2D known ✓ | O15399 | 7/20 | 0.91 |
| ▸ | GRIN3B known ✓ | O60391 | 7/20 | 0.91 |
| ▸ | GRIN2B known ✓ | Q13224 | 7/20 | 0.91 |
| ▸ | GRIN2C known ✓ | Q14957 | 7/20 | 0.91 |
| ▸ | GRIN3A known ✓ | Q8TCU5 | 7/20 | 0.91 |
| ▸ | LMNA | P02545 | 4/20 | 0.95 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.95 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.95 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.91 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.91 |
| ▸ | HTT | P42858 | 2/20 | 0.91 |
| ▸ | ESR1 | P03372 | 1/20 | 0.91 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.91 |
| ▸ | ACHE | P22303 | 1/20 | 0.91 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.91 |
| ▸ | MTOR | P42345 | 1/20 | 0.91 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.91 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Memantine SCHEMBL1659626 | 0.98 | GRIN1 (0.95) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL3053 | 0.98 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL27711131 | 0.98 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL6368832 | 0.98 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL31328273 | 0.98 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL2545234 | 0.98 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL28416563 | 0.95 | GRIN1 (0.95) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL23327176 | 0.95 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL2689 | 0.95 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL2688 | 0.95 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462743-B2 | Polymorphs of memantine hydrochloride | TEVA PHARMACEUTICAL FINE CHEMICALS S.R.L. (IT) | 2008-12-09 | — | — | US | disclosed |
| EP-1836154-A1 | POLYMORPHS OF MEMANTINE HYDROCHLORIDE | Teva Pharmaceutical Fine Chemicals S.R.L. (IT) | 2007-09-26 | — | — | EP | disclosed |
| US-20060217573-A1 | Polymorphs of memantine hydrochloride | TEVA PHARMACEUTICALS USA, INC. | 2006-09-28 | — | — | US | disclosed |
| WO-2006076560-A1 | POLYMORPHS OF MEMANTINE HYDROCHLORIDE | TEVA PHARMACEUTICAL FINE CHEMICALS S.R.L. (IT) | 2006-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060217573-A1 | Polymorphs of memantine hydrochloride | PSEN2, GRIN2A, HTR2A | GRIN1 40/4885GRIN2A 2/4885GRIN2D 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.