Known targets — ChEMBL curated mechanism
GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3B
The experimentally established mechanism targets of Memantine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 known ✓ | Q05586 | 10/20 | 1.00 |
| ▸ | GRIN2A known ✓ | Q12879 | 10/20 | 1.00 |
| ▸ | GRIN2D known ✓ | O15399 | 9/20 | 0.95 |
| ▸ | GRIN3B known ✓ | O60391 | 9/20 | 0.95 |
| ▸ | GRIN2B known ✓ | Q13224 | 9/20 | 0.95 |
| ▸ | GRIN2C known ✓ | Q14957 | 9/20 | 0.95 |
| ▸ | GRIN3A known ✓ | Q8TCU5 | 9/20 | 0.95 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.95 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.95 |
| ▸ | HTT | P42858 | 2/20 | 0.95 |
| ▸ | ESR1 | P03372 | 1/20 | 0.95 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.95 |
| ▸ | ACHE | P22303 | 1/20 | 0.95 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.95 |
| ▸ | MTOR | P42345 | 1/20 | 0.95 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.95 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Memantine SCHEMBL27711131 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL31328273 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL2545234 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL6368832 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL5011429 | 0.98 | GRIN1 (0.95) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL28416563 | 0.98 | GRIN1 (0.95) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL23327176 | 0.97 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL8126868 | 0.97 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL2688 | 0.97 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 | |
| Memantine SCHEMBL2689 | 0.97 | GRIN1 (1.00) | GRIN1GRIN2ALMNAPMP22NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 9710 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-121591615-B | Memantine derivative and synthesis method and application thereof | Shandong Xinhua Pharmaceutical Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122036494-A | Synthesis method and application of amantadine-butylphthalide eutectic | 佛山大学 | 2026-05-15 | — | — | CN | claimed |
| EP-4069232-B1 | MASUPIRDINE FOR TREATING BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS IN DEMENTIA | SUVEN LIFE SCIENCES LTD (IN) | 2025-12-24 | — | — | EP | claimed |
| US-20250375444-A1 | METHOD OF TREATING ALZHEIMER’S DISEASE | AMYRIAD PHARMA INC (US) | 2025-12-11 | — | — | US | claimed |
| US-20250333435-A1 | TIMOSAPONIN COMPOUNDS | GOLDPORP PHARMA LTD (CN) | 2025-10-30 | — | — | US | claimed |
| US-20250304565-A1 | NOVEL BENZOFURAN, BENZOTHIOPHENE, AND INDOLE ANALOGS THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE | Oligomerix Inc. (US) | 2025-10-02 | — | — | US | claimed |
| EP-3562483-B1 | NOVEL BENZOFURAN, BENZOTHIOPHENE, AND INDOLE ANALOGS THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE | OLIGOMERIX INC (US) | 2025-09-03 | — | — | EP | claimed |
| EP-4069231-B1 | COMBINATIONS OF MASUPIRDINE WITH DONEPEZIL OR MEMANTINE FOR TREATING BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS IN PATIENTS WITH DEMENTIA | SUVEN LIFE SCIENCES LTD (IN) | 2025-07-09 | — | — | EP | claimed |
| US-20250214984-A1 | COMPOUND HAVING KDM5 INHIBITORY ACTIVITY AND PHARMACEUTICAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2025-07-03 | — | — | US | claimed |
| EP-4146645-B1 | 3-AZABICYCLO(3.1.0)HEXANE DERIVATIVES HAVING KDM5 INHIBITORY ACTIVITY AND USE THEREOF | ONO PHARMACEUTICAL CO (JP) | 2025-06-25 | — | — | EP | claimed |
| WO-2004058258-A1 | THERAPEUTIC FORMULATIONS FOR THE TREATMENT OF BETA-AMYLOID RELATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2004-07-15 | — | — | WO | claimed |
| CN-1488622-A | Method for preparing memantine hydrochloride | 江苏省原子医学研究所 | 2004-04-14 | — | — | CN | claimed |
| CN-1486180-A | Methods for treating neuropsychiatric disorders with NMDA receptor antagonists | 纽热莫勒丘乐有限公司 | 2004-03-31 | — | — | CN | claimed |
| US-20040049134-A1 | System and methods for treatment of alzheimer's and other deposition-related disorders of the brain | TOSAYA CAROL A (US) | 2004-03-11 | — | — | US | claimed |
| CN-1125033-C | Synthesis of memantine hydrochloride | GUANGZHOU INST CHEMISTRY CAS (CN) | 2003-10-22 | — | — | CN | claimed |
| CN-1441704-A | Media milling | RTP PHARMA INC (CA) | 2003-09-10 | — | — | CN | claimed |
| CN-1406129-A | Methods for treating substance abuse | ALBERT SHULMAN (AU) | 2003-03-26 | — | — | CN | claimed |
| CN-1400205-A | Preparation method of memantine hydrochloride | GUANGZHOU INST OF CHEMISTRY (CN) | 2003-03-05 | — | — | CN | claimed |
| CN-1335299-A | Synthesis of memantine hydrochloride | GUANGZHOU INST OF CHEMISTRY AC (CN) | 2002-02-13 | — | — | CN | claimed |
| US-5955434-A | N-TERMINAL FMOC-PROTECTED PEPTIDE COMBINATIONS THAT FORM GELS IN WATER | BRIGHAM & WOMEN'S HOSPITAL (US) | 1999-09-21 | — | — | US | claimed |