Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CDC25B | P30305 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25453796 | 0.83 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CADRA1ACYP3A4 | |
| SCHEMBL25174770 | 0.81 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1ACYP3A4 | |
| SCHEMBL25168951 | 0.81 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CADRA1ACYP3A4 | |
| SCHEMBL25452384 | 0.81 | ADRA2A (0.62) | ADRA2AADRA2BADRA2CADRA1ACYP3A4 | |
| SCHEMBL26310703 | 0.80 | KDR (0.50) | CYP3A4ALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL30397687 | 0.80 | HSD17B10 (0.71) | ADRA2AADRA2BADRA2CADRA1ACYP3A4 | |
| SCHEMBL13432499 | 0.80 | HSD17B10 (0.71) | ADRA2AADRA2BADRA2CADRA1ACYP3A4 | |
| SCHEMBL25452376 | 0.79 | KDR (0.38) | ADRA2AADRA2BADRA2CADRA1ACYP3A4 | |
| SCHEMBL25452613 | 0.78 | RAB9A (0.60) | ADRA2AADRA2BADRA2CADRA1ACYP3A4 | |
| SCHEMBL25167313 | 0.73 | ADRA2A (0.65) | ADRA2AADRA2BADRA2CADRA1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081800-A1 | ALPHA-2A ADRENERGIC RECEPTOR MODULATORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-05-11 | — | — | WO | disclosed |