Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 2/20 | 0.31 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL964675 | 0.81 | PDE2A (0.32) | PDE2A | |
| SCHEMBL961782 | 0.73 | TRPA1 (0.33) | — | |
| SCHEMBL965660 | 0.70 | PSEN1 (0.34) | PDE2A | |
| SCHEMBL963387 | 0.69 | CYP17A1 (0.31) | — | |
| SCHEMBL962032 | 0.68 | AXL (0.33) | — | |
| SCHEMBL961836 | 0.66 | — | — | |
| SCHEMBL962703 | 0.66 | PSEN1 (0.51) | PDE2A | |
| SCHEMBL965146 | 0.66 | AXL (0.33) | — | |
| SCHEMBL961791 | 0.65 | PSEN1 (0.42) | — | |
| SCHEMBL2554009 | 0.64 | ALOX15 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379553-A1 | BICYCLIC COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | Bristol-Myers Squibb Company (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010083141-A1 | BICYCLIC COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-22 | — | — | WO | disclosed |