SCHEMBL25458155

SCHEMBL25458155

Cc1conc1C(=O)C(C)(C)C

nearest known ligand 0.36

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.36
ALDH1A1 P00352 2/20 0.31
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
NPC1 O15118 1/20 0.31
HPGD P15428 1/20 0.31
KMT2A Q03164 1/20 0.31
PTGS2 P35354 1/20 0.31
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1026251 0.77
SCHEMBL25562806 0.76
SCHEMBL1790158 0.75
SCHEMBL6639503 0.75
SCHEMBL13152133 0.72 CHRNA4 (0.43) ALDH1A1KDM4EMEN1NPC1HPGD
SCHEMBL25458161 0.72 BAZ2B (0.38) ALDH1A1KDM4EMEN1NPC1HPGD
SCHEMBL14627668 0.72 KDM4E (0.31) ALDH1A1KDM4EMEN1NPC1HPGD
SCHEMBL23367074 0.71 KDM4E (0.30) ALDH1A1KDM4EMEN1NPC1HPGD
SCHEMBL10645012 0.71 ALDH1A1 (0.30) ALDH1A1KDM4EMEN1NPC1HPGD
Hydrochloric Acid SCHEMBL23354312 0.69 LMNA (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230227437-A1 IMMUNOMODULATOR HITGEN INC (CN) 2023-07-20 US disclosed
US-20230159465-A1 IMMUNOMODULATOR HITGEN INC. (CN) 2023-05-25 US disclosed
EP-4183783-A1 IMMUNOMODULATOR Hitgen Inc. (CN) 2023-05-24 EP disclosed
EP-4177249-A1 IMMUNOMODULATOR Hitgen Inc. (CN) 2023-05-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230159465-A1 IMMUNOMODULATOR IL2, IL17A, IL2RA NPSR1 974/4885ALDH1A1 302/4885KDM4E 3572/4885
US-20230227437-A1 IMMUNOMODULATOR IL17A, IL2, IL2RA NPSR1 1563/4885ALDH1A1 261/4885KDM4E 3287/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.