Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 3/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2209905 | 1.00 | AHR (0.50) | AHRPBRM1LMNAMAPTHTT | |
| SCHEMBL2545956 | 1.00 | AHR (0.50) | AHRPBRM1LMNAMAPTHTT | |
| SCHEMBL8145740 | 0.77 | AHR (0.50) | AHRPBRM1LMNAMAPTHTT | |
| SCHEMBL6782580 | 0.77 | AHR (0.45) | AHRPBRM1LMNAMAPTHTT | |
| SCHEMBL3531221 | 0.77 | PBRM1 (0.57) | AHRPBRM1CA2CA9CYP2C9 | |
| SCHEMBL90908 | 0.74 | CREBBP (0.40) | MAPTCA2AKR1B1CYP1A2 | |
| SCHEMBL1291711 | 0.74 | AHR (0.42) | AHRPBRM1LMNAMAPTHTT | |
| SCHEMBL22633957 | 0.74 | AHR (0.38) | AHRPBRM1LMNAMAPTHTT | |
| SCHEMBL1044542 | 0.74 | PBRM1 (0.50) | AHRPBRM1LMNAMAPTHTT | |
| SCHEMBL16656033 | 0.74 | PBRM1 (0.50) | AHRPBRM1LMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342179-B1 | COMPOUNDS FOR INHIBITING SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) / VASCULAR ADHESION PROTEIN-1 (VAP-1) AND USES THEREOF FOR TREATMENT AND PREVENTION OF DISEASES | SEMMELWEIS EGYETEM (HU) | 2015-05-27 | — | — | EP | disclosed |
| US-8536210-B2 | Compounds for inhibiting semicarbazide-sensitive amine oxidase (SSAO)/vascular adhesion protein-1 (VAP-1) and uses thereof for treatment and prevention of diseases | SEMMELWEIS EGYETEM (HU) | 2013-09-17 | — | — | US | disclosed |
| US-20110263567-A1 | COMPOUNDS FOR INHIBITING SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) / VASCULAR ADHESION PROTEIN-1 (VAP-1) AND USES THEREOF FOR TREATMENT AND PREVENTION OF DISEASES | SEMMELWEIS EGYETEM (HU) | 2011-10-27 | — | — | US | disclosed |
| EP-1367056-A1 | Drugs that enhance synaptic responses mediated by AMPA receptors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-12-03 | — | — | EP | disclosed |
| EP-1156043-B1 | Drugs that enhance synaptic responses mediated by ampa receptors | UNIV CALIFORNIA (US) | 2003-11-12 | — | — | EP | disclosed |
| US-20020099050-A1 | Drugs that enhance synaptic responses mediated by AMPA receptors | LYNCH GARY S (US) | 2002-07-25 | — | — | US | disclosed |
| EP-0651746-B1 | DRUGS THAT ENHANCE SYNAPTIC RESPONSES MEDIATED BY AMPA RECEPTORS | UNIV CALIFORNIA (US) | 2002-03-27 | — | — | EP | disclosed |
| EP-1156043-A2 | Drugs that enhance synaptic responses mediated by ampa receptors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2001-11-21 | — | — | EP | disclosed |
| US-6274600-B1 | COGNITION ACTIVATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2001-08-14 | — | — | US | disclosed |
| US-5891876-A | ALPHA-AMINO-3-HYDROXY-5-METHYL-ISOXAZOLE-4-PROPIONIC ACID (AMPA); DRUGS THAT ENHANCE THESE RECEPTOR CURRENTS WILL FACILITATE COMMUNICATION IN BRAIN NETWORKS RESPONSIBLE FOR PERCEPTUAL-MOTOR INTEGRATION AND HIGHER ORDER BEHAVIORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-04-06 | — | — | US | disclosed |
| US-5852008-A | Heteroatom substituted benzoyl derivatives that enhance synaptic response mediated by receptors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-12-22 | — | — | US | disclosed |
| US-5747492-A | IMPROVING MEMORY; A-AMINO-3-HYDROXY-5-METHYL ISOOXAZOLE-4-PROPIONIC ACID | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-05-05 | — | — | US | disclosed |
| EP-0651746-A1 | DRUGS THAT ENHANCE SYNAPTIC RESPONSES MEDIATED BY AMPA RECEPTORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-05-10 | — | — | EP | disclosed |
| WO-1994002475-A1 | DRUGS THAT ENHANCE SYNAPTIC RESPONSES MEDIATED BY AMPA RECEPTORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1994-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263567-A1 | COMPOUNDS FOR INHIBITING SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) / VASCULAR ADHESION PROTEIN-1 (VAP-1) AND USES THEREOF FOR TREATMENT AND PREVENTION OF DISEASES | VCAM1, AOX1, AOC3 | AHR 2215/4885PBRM1 4582/4885LMNA 3134/4885 |
| US-20020099050-A1 | Drugs that enhance synaptic responses mediated by AMPA receptors | GABRE, GRIN1, GRIN3A | AHR 4598/4885PBRM1 3672/4885LMNA 4839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.