Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | GAK | O14976 | 6/20 | 0.50 |
| ▸ | SRC | P12931 | 3/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.50 |
| ▸ | COQ8A | Q8NI60 | 2/20 | 0.50 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.50 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.50 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.50 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.50 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.50 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 3/20 | 0.43 |
| ▸ | AXL | P30530 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25464971 | 1.00 | EGFR (0.54) | EGFRPDGFRAGAKSRCRIPK2 | |
| SCHEMBL25468866 | 0.93 | PDGFRA (0.46) | EGFRPDGFRAGAKSRCRIPK2 | |
| SCHEMBL25466677 | 0.88 | GAK (0.49) | PDGFRAGAKRIPK2COQ8ANLK | |
| SCHEMBL30417135 | 0.88 | GAK (0.49) | PDGFRAGAKRIPK2COQ8ANLK | |
| SCHEMBL25464965 | 0.88 | GAK (0.49) | PDGFRAGAKRIPK2COQ8ANLK | |
| SCHEMBL25466633 | 0.88 | GAK (0.49) | PDGFRAGAKRIPK2COQ8ANLK | |
| SCHEMBL25201258 | 0.88 | GAK (0.49) | PDGFRAGAKRIPK2COQ8ANLK | |
| SCHEMBL25468827 | 0.88 | GAK (0.49) | PDGFRAGAKRIPK2COQ8ANLK | |
| SCHEMBL25465686 | 0.84 | HTR1A (0.47) | PDGFRAGAK | |
| SCHEMBL24028612 | 0.83 | EGFR (0.54) | EGFRPDGFRAGAKSRCRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023086638-A1 | ENPP1 MODULATORS AND USES THEREOF | Vir Biotechnology, Inc. (US) | 2023-05-19 | — | — | WO | disclosed |