Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 4/20 | 0.35 |
| ▸ | TYK2 | P29597 | 4/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | GALR2 | O43603 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | CCR6 | P51684 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24525182 | 0.90 | DHODH (0.36) | DHODHMAPTKDM4ETGFBR1JAK1 | |
| SCHEMBL24525000 | 0.88 | CFTR (0.37) | DHODHMAPTKDM4ETGFBR1 | |
| SCHEMBL29654506 | 0.88 | CFTR (0.37) | DHODHMAPTKDM4ETGFBR1 | |
| SCHEMBL25486953 | 0.85 | JAK2 (0.46) | DHODHMAPTKDM4ETGFBR1TYK2 | |
| SCHEMBL24525117 | 0.81 | KDM4E (0.42) | DHODHMAPTKDM4ETGFBR1JAK1 | |
| SCHEMBL25484858 | 0.76 | ALPL (0.43) | MAPTKDM4EDYRK1ASMN1; SMN2ALDH1A1 | |
| SCHEMBL25485749 | 0.75 | SLC6A4 (0.52) | KDM4ESMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL25485799 | 0.75 | ALDH1A1 (0.42) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL25486723 | 0.73 | ABL1 (0.44) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL24525459 | 0.72 | JAK2 (0.43) | DHODHMAPTKDM4ETGFBR1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159563-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159563-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | KRAS, NRAS, HRAS | DHODH 475/4885MAPT 4642/4885KDM4E 2592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.