Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25487554 | 0.92 | P2RX7 (0.38) | P2RX7KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL25487564 | 0.92 | P2RX7 (0.38) | P2RX7KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL25487717 | 0.86 | MAPK1 (0.34) | P2RX7KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL25487906 | 0.85 | LCK (0.35) | P2RX7KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL25487914 | 0.85 | LCK (0.35) | P2RX7KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL25490145 | 0.84 | KDM4E (0.37) | P2RX7KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL17588998 | 0.83 | KDM4E (0.41) | KMT2AMEN1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL25487994 | 0.82 | P2RX7 (0.35) | P2RX7KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL22895320 | 0.81 | KDM4E (0.34) | KMT2AMEN1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL22895289 | 0.81 | KDM4E (0.34) | KMT2AMEN1SMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11655257-B2 | MK2 inhibitors, synthesis thereof, and intermediates thereto | CELGENE CAR LLC (BM) | 2023-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11655257-B2 | MK2 inhibitors, synthesis thereof, and intermediates thereto | WEE2, WEE1, CDK2 | P2RX7 3185/4885KMT2A 168/4885MEN1 1195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.