Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25487573 | 0.86 | KMT2A (0.51) | PLA2G2AKMT2AMEN1SMN1; SMN2DHODH | |
| SCHEMBL3837660 | 0.84 | P2RX7 (0.48) | KMT2AP2RX7SMN1; SMN2DHODHKDM4E | |
| SCHEMBL12571909 | 0.83 | P2RX7 (0.47) | KMT2AP2RX7TP53SMN1; SMN2DHODH | |
| SCHEMBL543109 | 0.77 | PLA2G2A (0.44) | PLA2G2AKMT2AMEN1TP53SMN1; SMN2 | |
| SCHEMBL610102 | 0.74 | S1PR4 (0.56) | KMT2AMEN1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL17311005 | 0.73 | KDM4E (0.38) | PLA2G2AKMT2AMEN1P2RX7KDM4E | |
| SCHEMBL25096345 | 0.73 | KDM4E (0.50) | KMT2AMEN1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL5129388 | 0.72 | TAAR1 (0.57) | KMT2AP2RX7SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL16131036 | 0.72 | KMT2A (0.56) | KMT2AMEN1KDM4EPOLBALDH1A1 | |
| SCHEMBL30251615 | 0.72 | TP53 (0.65) | KMT2AMEN1TP53KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11655257-B2 | MK2 inhibitors, synthesis thereof, and intermediates thereto | CELGENE CAR LLC (BM) | 2023-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11655257-B2 | MK2 inhibitors, synthesis thereof, and intermediates thereto | WEE2, WEE1, CDK2 | PLA2G2A 965/4885KMT2A 168/4885MEN1 1195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.