Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2145658 | 0.98 | ALDH1A1 (0.45) | CNR2PIK3CDPIK3CAPIK3CBALDH1A1 | |
| SCHEMBL2340680 | 0.87 | PIK3CD (0.63) | CNR2PIK3CDPIK3CAPIK3CBALDH1A1 | |
| SCHEMBL27665211 | 0.84 | CNR2 (0.42) | CNR2PIK3CDPIK3CAPIK3CBALDH1A1 | |
| SCHEMBL2145953 | 0.79 | SMN1; SMN2 (0.41) | CNR2PIK3CDPIK3CAPIK3CBALDH1A1 | |
| SCHEMBL2545715 | 0.79 | ALDH1A1 (0.45) | ALDH1A1HTTNPSR1HPGDMEN1 | |
| SCHEMBL2145802 | 0.79 | MLYCD (0.52) | CNR2ALDH1A1HTTTDP1SMN1; SMN2 | |
| SCHEMBL12246273 | 0.78 | ALDH1A1 (0.45) | ALDH1A1HTTNPSR1HPGDMEN1 | |
| SCHEMBL3736844 | 0.77 | HRH4 (0.41) | CNR2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL3736842 | 0.77 | HRH4 (0.41) | CNR2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL13787617 | 0.76 | PIK3CD (0.74) | PIK3CDPIK3CAPIK3CBALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8507490-B2 | Tetrasubstituted pyridazine hedgehog pathway antagonists | ELI LILLY AND COMPANY (US) | 2013-08-13 | — | — | US | disclosed |
| US-8507490-B2 | Tetrasubstituted pyridazine hedgehog pathway antagonists | ELI LILLY AND COMPANY (US) | 2013-08-13 | — | — | US | disclosed |
| US-8507490-B2 | Tetrasubstituted pyridazine hedgehog pathway antagonists | ELI LILLY AND COMPANY (US) | 2013-08-13 | — | — | US | disclosed |
| EP-2358698-B1 | TETRASUBSTITUTED PYRIDAZINE AS HEDGEHOG PATHWAY ANTAGONISTS | LILLY CO ELI (US) | 2012-09-05 | — | — | EP | disclosed |
| EP-2358698-B1 | TETRASUBSTITUTED PYRIDAZINE AS HEDGEHOG PATHWAY ANTAGONISTS | LILLY CO ELI (US) | 2012-09-05 | — | — | EP | disclosed |
| US-20110263602-A1 | TETRASUBSTITUTED PYRIDAZINE HEDGEHOG PATHWAY ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-10-27 | — | — | US | disclosed |
| US-20110263602-A1 | TETRASUBSTITUTED PYRIDAZINE HEDGEHOG PATHWAY ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-10-27 | — | — | US | disclosed |
| US-20110263602-A1 | TETRASUBSTITUTED PYRIDAZINE HEDGEHOG PATHWAY ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-10-27 | — | — | US | disclosed |
| WO-2010056588-A1 | TETRASUBSTITUTED PYRIDAZINE HEDGEHOG PATHWAY ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2010-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263602-A1 | TETRASUBSTITUTED PYRIDAZINE HEDGEHOG PATHWAY ANTAGONISTS | SHH, SMO, GLI1 | CNR2 52/4885PIK3CD 2058/4885PIK3CA 2284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.