Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL247421 | 0.82 | IDO1 (0.45) | ESR1IDO1ADRB1SLC6A4SLC6A2 | |
| SCHEMBL564834 | 0.82 | SLC6A2 (0.63) | IDO1ADRB1SLC6A4SLC6A2HTR2A | |
| SCHEMBL6685103 | 0.82 | ESR1 (0.74) | ESR1THRATHRBSLC6A4SLC6A2 | |
| Hydrochloric Acid SCHEMBL8528039 | 0.80 | SLC6A2 (0.61) | IDO1ADRB1SLC6A4SLC6A2HTR2A | |
| SCHEMBL9746418 | 0.80 | IDO1 (0.44) | ESR1IDO1ADRB1SLC6A4SLC6A2 | |
| SCHEMBL25449042 | 0.80 | ESR1 (0.44) | ESR1IDO1ADRB1THRATHRB | |
| SCHEMBL12050478 | 0.79 | IDO1 (0.47) | IDO1ADRB1PYCR1L3MBTL1TYR | |
| SCHEMBL18367846 | 0.79 | ESR1 (0.52) | ESR1THRATHRBSLC6A4SLC6A2 | |
| SCHEMBL23395239 | 0.79 | IDO1 (0.42) | ESR1IDO1ADRB1SLC6A4SLC6A2 | |
| SCHEMBL28092599 | 0.79 | ESR1 (0.47) | ESR1THRATHRBSLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11661418-B2 | MASP-2 inhibitors and methods of use | OMEROS CORPORATION (US) | 2023-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11661418-B2 | MASP-2 inhibitors and methods of use | MASP2, METAP2, SPINT2 | ESR1 4540/4885IDO1 3850/4885ADRB1 4594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.