Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.58 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | AHCY | P23526 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.37 |
| ▸ | ALB | P02768 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.37 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL155990 | 1.00 | FGFR1 (0.58) | FGFR1SLC22A6ADORA2AAHCYLMNA | |
| SCHEMBL24420123 | 1.00 | FGFR1 (0.58) | FGFR1SLC22A6ADORA2AAHCYLMNA | |
| SCHEMBL140792 | 0.86 | FGFR1 (0.50) | FGFR1SLC22A6LMNATHRBMTOR | |
| SCHEMBL8621597 | 0.86 | FGFR1 (0.50) | FGFR1SLC22A6LMNATHRBMTOR | |
| SCHEMBL18069556 | 0.86 | FGFR1 (0.50) | FGFR1SLC22A6LMNATHRBMTOR | |
| SCHEMBL5180818 | 0.84 | FGFR1 (0.55) | FGFR1SLC22A6LMNATHRBMTOR | |
| SCHEMBL14948806 | 0.83 | FGFR1 (0.56) | FGFR1SLC22A6LMNATHRBMTOR | |
| SCHEMBL10049650 | 0.83 | FGFR1 (0.56) | FGFR1SLC22A6LMNATHRBMTOR | |
| SCHEMBL7269776 | 0.82 | FGFR1 (0.52) | FGFR1SLC22A6ADORA2ALMNATHRB | |
| SCHEMBL7269771 | 0.82 | FGFR1 (0.52) | FGFR1SLC22A6ADORA2ALMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240026358-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2024-01-25 | — | — | US | disclosed |
| US-20240026358-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2024-01-25 | — | — | US | disclosed |
| WO-2023220428-A1 | COMPOSITIONS FOR EDITING ASS1 TRANSCRIPTS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2023-11-16 | — | — | WO | disclosed |
| WO-2023220440-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2023-11-16 | — | — | WO | disclosed |
| WO-2022099159-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2022-05-12 | — | — | WO | disclosed |
| CN-110845560-B | Phenylalanine amidated nucleotide derivative and preparation method and application thereof | 广东中科药物研究有限公司 | 2021-08-24 | — | — | CN | disclosed |
| CN-110845560-A | Phenylalanine amidated nucleotide derivative and preparation method and application thereof | 广东中科药物研究有限公司 | 2020-02-28 | — | — | CN | disclosed |
| EP-3020720-B1 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | CHIMERIX INC (US) | 2018-09-19 | — | — | EP | disclosed |
| EP-2611818-B1 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | CHIMERIX INC (US) | 2016-08-24 | — | — | EP | disclosed |
| EP-3020720-A1 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | Chimerix, Inc. (US) | 2016-05-18 | — | — | EP | disclosed |
| US-20140046085-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | CHIMERIX, INC. (US) | 2014-02-13 | — | — | US | disclosed |
| US-8569321-B2 | Phosphonate ester derivatives and methods of synthesis thereof | CHIMERIX, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| EP-2611818-A2 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | Chimerix, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012031045-A2 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | CHIMERIX, INC. (US) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012031045-A2 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | CHIMERIX, INC. (US) | 2012-03-08 | — | — | WO | disclosed |
| US-8063209-B2 | Phosphonyl ester conjugates as prodrugs | TSRL, INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-20090270618-A1 | PHOSPHONYL ESTER CONJUGATES AS PRODRUGS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-10-29 | — | — | US | disclosed |
| EP-0574386-B1 | NOVEL PROCESS FOR THE PREPARATION OF NUCLEOTIDES | ACAD OF SCIENCE CZECH REPUBLIC (CZ) | 2000-06-28 | — | — | EP | disclosed |
| US-5591852-A | Process for the preparation of nucleotides | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) | 1997-01-07 | — | — | US | disclosed |
| US-5476938-A | Process for the preparation of nucleotides | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1995-12-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140046085-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | PHOSPHO1, PIK3CA, PNP | FGFR1 2756/4885SLC22A6 3161/4885ADORA2A 538/4885 |
| US-20090270618-A1 | PHOSPHONYL ESTER CONJUGATES AS PRODRUGS | DNPEP, PHOSPHO1, TYMP | FGFR1 1739/4885SLC22A6 986/4885ADORA2A 2278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.