Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.31 |
| ▸ | PTPRB | P23467 | 2/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 2/20 | 0.30 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2549200 | 0.91 | ATM (0.33) | ATMCYP3A4PTPRBCTSSCTSK | |
| SCHEMBL2549204 | 0.91 | ATM (0.33) | ATMCYP3A4PTPRBCTSSCTSK | |
| SCHEMBL1742999 | 0.85 | ATM (0.31) | ATMCTSSCTSK | |
| SCHEMBL2549235 | 0.85 | ATM (0.31) | ATMCTSSCTSK | |
| SCHEMBL1744963 | 0.85 | ATM (0.34) | ATMCYP3A4PTPRBCTSSCTSK | |
| SCHEMBL1744961 | 0.85 | ATM (0.34) | ATMCYP3A4PTPRBCTSSCTSK | |
| SCHEMBL2545438 | 0.81 | ATM (0.37) | ATMCYP3A4PTPRBCTSSCTSK | |
| SCHEMBL2545442 | 0.81 | ATM (0.37) | ATMCYP3A4PTPRBCTSSCTSK | |
| SCHEMBL2547638 | 0.80 | ATM (0.36) | ATMCYP3A4PTPRBCTSSCTSK | |
| SCHEMBL2547634 | 0.80 | ATM (0.36) | ATMCYP3A4PTPRBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263647-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263647-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | TFEB, PCK2, JAK2 | ATM 332/4885CYP3A4 2741/4885PTPRB 879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.