Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.84 |
| ▸ | MTOR | P42345 | 5/20 | 0.84 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.84 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.84 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.84 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.81 |
| ▸ | PRKDC | P78527 | 1/20 | 0.81 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.81 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.81 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.81 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.81 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.81 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.81 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.81 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25495121 | 0.93 | PIK3CA (0.76) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL21964236 | 0.93 | PIK3CA (0.82) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL25495123 | 0.92 | PIK3CA (0.74) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL17060456 | 0.91 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL17060446 | 0.91 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL741445 | 0.91 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL17060445 | 0.91 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL25495122 | 0.90 | PIK3CA (0.83) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1300383 | 0.90 | PIK3CA (0.86) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL17060435 | 0.90 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240238458-A1 | COMPOUNDS TARGETING FIBROBLAST-ACTIVATION PROTEIN AND METHODS OF USE THEREOF | PURDUE RESEARCH FOUNDATION | 2024-07-18 | — | — | US | disclosed |
| US-20230158153-A1 | PI3 KINASE INHIBITORS AND USES THEREOF | PURDUE RESEARCH FOUNDATION | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230158153-A1 | PI3 KINASE INHIBITORS AND USES THEREOF | MMP1, PIK3CA, AKT2 | PIK3CA 2/4885MTOR 34/4885PIK3CD 7/4885 |
| US-20240238458-A1 | COMPOUNDS TARGETING FIBROBLAST-ACTIVATION PROTEIN AND METHODS OF USE THEREOF | FAP, FIBP, FGFR1 | PIK3CA 2195/4885MTOR 1789/4885PIK3CD 3476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.