Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.79 |
| ▸ | GAA | P10253 | 1/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CTSK | P43235 | 7/20 | 0.49 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17150407 | 0.92 | MEN1 (0.77) | MEN1KMT2AGAATDP1CTSK | |
| SCHEMBL26520283 | 0.90 | MEN1 (0.72) | MEN1KMT2AGAATDP1CTSK | |
| SCHEMBL17079742 | 0.90 | MEN1 (0.72) | MEN1KMT2AGAATDP1CTSK | |
| SCHEMBL25090844 | 0.89 | MEN1 (0.88) | MEN1KMT2AGAATDP1CTSK | |
| SCHEMBL5749667 | 0.89 | MEN1 (0.77) | MEN1KMT2AGAATDP1CTSK | |
| SCHEMBL18704730 | 0.89 | MEN1 (0.77) | MEN1KMT2AGAATDP1CTSK | |
| SCHEMBL24117848 | 0.85 | TDP1 (0.59) | MEN1KMT2AGAATDP1CTSK | |
| SCHEMBL17424026 | 0.85 | MEN1 (0.57) | MEN1KMT2AGAATDP1CTSK | |
| SCHEMBL6200619 | 0.84 | MEN1 (0.64) | MEN1KMT2AGAATDP1CTSK | |
| SCHEMBL6200616 | 0.84 | MEN1 (0.64) | MEN1KMT2AGAATDP1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023086399-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |