Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.45 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2548197 | 0.84 | PIK3CD (0.45) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL2576817 | 0.82 | PIK3CD (0.44) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL2507138 | 0.79 | PIK3CD (0.71) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL2509378 | 0.79 | PIK3CD (0.71) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL2550124 | 0.75 | PIK3CD (0.41) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL2548362 | 0.75 | BRAF (0.37) | — | |
| SCHEMBL2717991 | 0.74 | PIK3CD (0.43) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL2718760 | 0.72 | PIK3CD (0.43) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL2548473 | 0.71 | PIK3CD (0.64) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL12264096 | 0.70 | CYP2A6 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552908-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011123751-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-10-06 | — | — | WO | disclosed |