Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | HSD11B1 | P28845 | 10/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HSD11B2 | P80365 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.48 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27024183 | 1.00 | ALDH1A1 (0.63) | ALDH1A1TSHRHSD11B1SMN1; SMN2HSD11B2 | |
| SCHEMBL20827024 | 0.92 | ALDH1A1 (0.63) | ALDH1A1TSHRHSD11B1SMN1; SMN2HSD11B2 | |
| SCHEMBL3283711 | 0.92 | HPGD (0.56) | ALDH1A1TSHRHSD11B1SMN1; SMN2HSD11B2 | |
| SCHEMBL4156159 | 0.90 | ALDH1A1 (0.72) | ALDH1A1TSHRHSD11B1SMN1; SMN2HSD11B2 | |
| SCHEMBL4150572 | 0.88 | ALDH1A1 (0.68) | ALDH1A1TSHRHSD11B1SMN1; SMN2HSD11B2 | |
| SCHEMBL4696770 | 0.85 | HSD11B1 (0.69) | ALDH1A1TSHRHSD11B1SMN1; SMN2HSD11B2 | |
| SCHEMBL1344660 | 0.83 | ALDH1A1 (0.61) | ALDH1A1TSHRHSD11B1SMN1; SMN2HPGD | |
| SCHEMBL3720831 | 0.80 | MAPT (0.55) | ALDH1A1TSHRHSD11B1HSD11B2HPGD | |
| SCHEMBL2875954 | 0.79 | NOTUM (0.46) | ALDH1A1LMNA | |
| SCHEMBL652433 | 0.79 | NOTUM (0.46) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023086399-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |