Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.43 |
| ▸ | IKZF3 | Q9UKT9 | 4/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.43 |
| ▸ | HPGDS | O60760 | 2/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24299447 | 0.88 | CRBN (0.55) | CRBNDDB1PDK2ALDH1A1 | |
| SCHEMBL25188645 | 0.86 | CRBN (0.61) | CRBNIKZF3DDB1HPGDSAR | |
| SCHEMBL24299444 | 0.82 | CRBN (0.54) | CRBNDDB1PDK2ALDH1A1 | |
| SCHEMBL24481058 | 0.82 | CRBN (0.48) | CRBNDDB1PDK2 | |
| SCHEMBL20046318 | 0.81 | CRBN (0.54) | CRBNDDB1PDK2ALDH1A1 | |
| SCHEMBL21946901 | 0.80 | CRBN (0.42) | CRBNDDB1HPGDSAR | |
| SCHEMBL22951135 | 0.80 | CRBN (0.48) | CRBNDDB1PDK2 | |
| SCHEMBL22291548 | 0.80 | CRBN (0.46) | CRBNDDB1PDK2ALDH1A1 | |
| SCHEMBL29223778 | 0.80 | CRBN (0.43) | CRBNDDB1HPGDSAR | |
| SCHEMBL24031989 | 0.79 | CRBN (0.40) | CRBNIKZF3DDB1ARBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023086399-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |