SCHEMBL25511368

SCHEMBL25511368

COc1nc(-c2ccc(C(F)(F)F)nc2)nc(Nc2ccc(C)cc2)c1C(F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 2/20 0.42
MAPT P10636 3/20 0.37
TP53 P04637 2/20 0.37
KDM1A O60341 1/20 0.37
CHRNA7 P36544 2/20 0.36
MAPK1 P28482 1/20 0.36
HTT P42858 1/20 0.36
ABCG2 Q9UNQ0 3/20 0.36
LMNA P02545 1/20 0.36
LATS1 O95835 1/20 0.36
MEN1 O00255 1/20 0.35
GBA1 P04062 1/20 0.35
KMT2A Q03164 1/20 0.35
HDAC4 P56524 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
TRPV1 Q8NER1 1/20 0.35
ABCB1 P08183 1/20 0.35
PDE10A Q9Y233 1/20 0.34
TRPV3 Q8NET8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30151232 1.00 PTGS2 (0.42) PTGS2MAPTTP53KDM1ACHRNA7
SCHEMBL25511362 0.89 KDM1A (0.48) MAPTTP53KDM1ACHRNA7MAPK1
SCHEMBL25511385 0.89 KDM1A (0.39) PTGS2MAPTTP53KDM1ACHRNA7
SCHEMBL30151271 0.89 KDM1A (0.48) MAPTTP53KDM1ACHRNA7MAPK1
SCHEMBL25511339 0.83 MAPT (0.56) MAPTTP53KDM1AMAPK1HTT
SCHEMBL25511342 0.82 LATS1 (0.52) MAPTTP53ABCG2LMNALATS1
SCHEMBL25511404 0.81 HIF1A (0.36) PTGS2MAPTTP53ABCG2LMNA
SCHEMBL30151281 0.78 MAPT (0.43) PTGS2MAPTHTTLMNAMEN1
SCHEMBL25511399 0.78 ABCG2 (0.41) MAPTTP53MAPK1HTTABCG2
SCHEMBL29635376 0.78 PDE10A (0.43) HDAC1HDAC6PDE10ATRPV3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118251386-A Fluoropyrimidine compound, harmful fungus control agent, and process for producing fluoropyrimidine compound 优迈特株式会社 2024-06-25 CN disclosed
WO-2023085142-A1 FLUORINE-CONTAINING PYRIMIDINE COMPOUNDS, HARMFUL FUNGI CONTROL AGENT, AND METHOD FOR PRODUCING FLUORINE-CONTAINING PYRIMIDINE COMPOUNDS ユニマテック株式会社 2023-05-19 WO disclosed