Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 19/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2522954 | 0.89 | GPR119 (0.65) | GPR119KCNH2 | |
| SCHEMBL2450345 | 0.86 | GPR119 (0.68) | GPR119KCNH2 | |
| SCHEMBL2521773 | 0.85 | GPR119 (0.69) | GPR119KCNH2SLC6A9 | |
| Bms-903452 SCHEMBL2518877 | 0.82 | GPR119 (1.00) | GPR119KCNH2 | |
| SCHEMBL2455244 | 0.82 | GPR119 (0.63) | GPR119KCNH2CYP2C9 | |
| SCHEMBL2576759 | 0.82 | GPR119 (0.70) | GPR119KCNH2 | |
| SCHEMBL12213567 | 0.82 | GPR119 (0.89) | GPR119KCNH2 | |
| SCHEMBL2581102 | 0.81 | GPR119 (0.70) | GPR119KCNH2 | |
| SCHEMBL2516235 | 0.80 | GPR119 (1.00) | GPR119KCNH2SLC6A9 | |
| SCHEMBL2454314 | 0.77 | GPR119 (0.60) | GPR119KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556069-A1 | PYRIMIDINYLPIPERIDINYLOXYPYRIDINONE ANALOGUES AS GPR119 MODULATORS | Bristol-Myers Squibb Company (US) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011127106-A1 | PYRIMIDINYLPIPERIDINYLOXYPYRIDINONE ANALOGUES AS GPR119 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-10-13 | — | — | WO | disclosed |